PhosphodiesteraseEnzyme (PDE) Inhibitors Market - Global Industry Insights, Trends, Outlook,and Opportunity Analysis, 2018-2026
Phosphodiesterase are a diversefamily of enzymes (11 isoenzymes) that play a key role in regulatingintracellular levels of secondary messengers - cyclic adenosine monophosphate(cAMP) and cyclic guanosine monophosphate. These enzymes identified to bepharmacologically active in the 1950s, hydrolyses cyclic nucleotides to treatvarious diseases such as cardiovascular, respiratory and erectile dysfunction.Distinct distribution of all the types of isoenzymes has provided possibilitiesfor selective target therapies.
The global phosphodiesteraseenzyme inhibitors market can be better analyzed by classifying it into twoclasses as selective phosphodiesterase enzyme inhibitors and non-selectivephosphodiesterase enzyme inhibitors. Theophylline and papaverineare the twomost commonly used non-selective phosphodiesterase enzyme inhibitors fortreating a range of diseases (bronchodilation, cardiac disorder, etc.). Adventof selective phosphodiesterase enzyme inhibitors has made a great impact in themedical treatment sector. Increasing understanding of the individual PDEisoforms has and will result in the emergence of better therapeutic drugs.Viagra (Sildenafil) is the best example to substantiate the success and impactof PDE inhibitors.
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The global phosphodiesteraseenzyme inhibitors market is majorly driven by PDE-5 inhibitors realizing thesuccess of blockbuster drugs in these segment.
Increasing product developmentsto further improvise the phosphodiesterase enzyme inhibitors market outlook
The global phosphodiesteraseenzyme inhibitors market has recently gained traction on account of theblockbuster PDE 5 inhibitor brands, Viagra and Cialis. This has also encouragedpharmaceutical companies to research on other PDE inhibitor class. In addition,research on extended use of approved PDE inhibitors is anticipated to benefitthe drug in long term and contribute to the increasing revenues of PDEinhibitors market.
Researchers from the John HopkinUniversity reviewed the trials of PDE-5 inhibitors in pediatric patients withpulmonary hypertension. The researchers concluded that PDE-5 inhibitors can besafely prescribed to infants, neonates and children with primary and secondarypulmonary hypertension (2017).
Besides, PDE-5 inhibitorsildenafil accidently developed for treating angina, was also found to beeffective in erectile dysfunction and now is observed to benefit heart attackpatients. Researchers at Karolinska Institutet, Sweden reported in March 2017that PDE-5 inhibitors prescribed for erectile dysfunction can lower the risk ofdeath of hospitalization for heart failure in men who have had one heart attackin their lifetime.
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Pfizer, Inc. received FDAapproval for its PDE-4 inhibitor Crisaborole (Eucris) in December 2016 for thetreatment of mild to moderate atopic dermatitis. Eucrisa the firstnon-steroidal topical monotherapy for skin disorder.
Many such product developmentswould be augmenting the global PDE inhibitors market growth in near future.
New products are primarilytargeted in develop economies like North America, Europe and Japan. However,product approval in emerging nations such as India, China, Brazil, Russia,Argentina, and Indonesia would potentially favorable for the market players.Increasing healthcare expenditure and large target population base wouldsupport the growth of PDE inhibitors market in these nations. However, marketplayers need to be cautious about uncertain regulatory conditions favoring theeconomic status and healthcare need of the large patient population.
Some of the key players operatingin the global phosphodiesterase enzyme inhibitors market include Pfizer, Inc.,AstraZeneca plc, Bayer AG, Eli Lilly & Company, Celgene Corporation, MistPharmaceuticals.
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