Single-cell bioinformatics analysis is required for the normalization due to amplification biases introduced by scarce amounts of initiating DNA/RNA material. Single cell analysis aims to recognize the differences between cells. The analysis provides a new arena for bioinformatics, as bulk-cell data analysis methods may not be directly applicable to single-cell data.
The global single cell bioinformatics software and services market was estimated to be at $205.2 million in 2020, which is expected to grow with a CAGR of 10.89% and reach $634.8 million by 2031. The growth in the global single cell bioinformatics software and services market is expected to be driven by an increasing number of bioinformatics services being offered for computational analysis and a rising number of open-source free platform providers offering single cell analysis software.
Impact of COVID-19
Most of the single cell studies focused on the progression of COVID-19 and have provided important molecular and immune characteristics. Researchers have analyzed large-scale single cell integrated data, which included single cell sequencing data of 140 different types of samples from 104 COVID-19 patients. Through this, they gained insights into the immune cell proportions of peripheral blood mononuclear cells (PBMCs), Tcell receptor (TCR) clone diversity, and other characteristics in convalescent patients. Another research study showcased profiled adaptive immune cells of PBMCs from recovered COVID-19 patients who have varying disease severity using single cell RNA sequencing, single cell TCR sequencing, and single cell BCR sequencing. Scientists have discovered a phenomenon that is hard to explain by these studies, which shows that convalescent patients with high serum anti-spike titers produce a higher proportion of non-neutralizing antibodies. Researchers have also performed single cell RNA sequencing on COVID-19 patient samples, which helped them compare the differences in gene expression patterns in patients of varying infection severity and in different organ types to analyze organ injury. They also found that COVID-19 infection leads to the inflammation of genes and pathways, which result in organ tissue damage to the liver, lungs, kidney, and heart. Through their study, they concluded that treating these symptoms at the organ level with therapeutic targets in the inflammatory pathway’s axis can lead to a better prognosis for severely infected patients.
Market Segmentation:
• Segmentation 1: by Products
o Bioinformatics Software
o Bioinformatics Services
The global single cell bioinformatics software and services market in the products segment is expected to be dominated by the bioinformatics services segment. This is due to an increasing number of bioinformatics service providers offering services to their end users.
• Segmentation 2: by Applications
o Oncology
o Immunology
o Neurology
o Non-invasive Prenatal Diagnosis (NIPD)
o Microbiology
o Other Applications
The global single cell bioinformatics software and services market is dominated by the oncology segment owing to an increasing number of patients suffering from cancer. According to the data published by World Health Organization, cancer is a leading cause of death, with nearly 10 million deaths reported in 2020.
• Segmentation 3: by End-User
o Research and Academic Institutes
o Biopharmaceutical Companies
o Others
The research and academic institutes segment dominates the global single cell bioinformatics software and services market due to the increasing research and development activities in academic institutes and the focus of researchers on single cell analysis.
• Segmentation 3: by Region
o North America - U.S., Canada
o Europe – U.K., Germany, France, Italy, Spain, and Rest-of-Europe
o Asia-Pacific - Japan, China, India, South Korea, Australia, and Rest-of-Asia-Pacific
o Latin America - Brazil, Mexico, and Rest of Latin America
o Rest-of-the-World
North America generated the highest revenue of $103.0 million in 2020, which is attributed to the RD advancements in the field of single cell analysis and the presence of dominating players operating in the single cell bioinformatics and services market.
Recent Developments in Global Single Cell Bioinformatics Software and Services Market
• In December 2019, Nanostring developed a strategic license for diagnostic equipment based on nCounter for single cell and rights to Veracyte for $50 million and Veracyte stock, plus up to $10 million after satisfying future events.
• In June 2021, Bruker Corporation launched the Tims TOF SCP system to provide quantitative single-cell 4D-Proteomics.
• In September 2019, IsoPlexis expanded the sales of its single-cell proteomic research platforms, IsoLight and IsoCode Chip, to the Japanese pharmaceutical and life sciences industry by partnering with BioStream Co.
• In January 2021, the company launched a new standard in spatial biology for high-speed imaging of whole slides at single-cell and sub-cellular resolution.
Key Market Players and Competition Synopsis
The companies that are profiled have been selected based on inputs gathered from primary experts and analyzing company coverage, product portfolio, and market penetration.
The leading top segment players include single cell bioinformatics services manufacturers that capture around 95% of the presence in the market. Bioinformatics software contributes around 5% of the presence in the market.
Some of the prominent names established in this market are:
Company Type 1: Bioinformatics Services
• Fluidigm Corporation
• QIAGEN
• Mission Bio
• Illumina, Inc.
Company Type 2: Bioinformatics Software
• Takara Inc.
• BD.
• PacBio
Companies that are not a part of the above-mentioned pool have been well represented across different sections of the report (wherever applicable).
Key Questions Answered in the Report
- How is single cell bioinformatics software and services revolutionizing the field of single cell analysis field?
- What are the major market drivers, challenges, and opportunities in the global single cell bioinformatics software and services market?
- What are the underlying structures resulting in the emerging trends within the global single cell bioinformatics software and services market?
- How did the COVID-19 pandemic impact the global single cell bioinformatics software and services ecosystem?
- What are the key development strategies that are being implemented by major players in order to sustain themselves in the competitive market?
- What are the key regulatory implications in developed and developing regions pertaining to the use of single cell bioinformatics software and services?
- What are the potential entry barriers that are expected to be faced by companies willing to enter a particular region?
- How is each segment of the market expected to grow during the forecast period 2021-2031, and what is the anticipated revenue to be generated by each of the segments? Following are the segments:
- Product (Bioinformatics Software and Bioinformatics Service)
- Application (Oncology, Immunology, Neurology, Non-invasive Prenatal Diagnosis (NIPD), Microbiology, Others)
- End-user (Biopharmaceutical Companies, Research and Academic Institutes, Others)
- Region (North America, Europe, Asia-Pacific, Latin America, and Rest-of-the-World)
- What are the growth opportunities for companies in the region of their operation?
- Who are the leading players with significant offerings in the global single cell bioinformatics software and services market?
- Which companies are anticipated to be highly disruptive in the future, and why?
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