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Most healthcare providers and physicians claim that the most common reactions caused by these products are allergic reactions, gastrointestinal disturbances, and rashes. The incidence of allergic reactions may vary, based on individual immunity and exposure to allergens. Rashes and hives are considered to be signs of allergies when they occur in conjunction with red bumps resembling a skin rash. According to medical experts, hives that occur due to the use of these products are considered to be a type of allergic reaction caused by the action of some of the chemical components of these coagulation factors. It should be noted that although the use of Recombinant Therapeutic Antibodies and Proteins has reduced the incidence of allergic reactions, it is still important that precautionary measures are taken to avoid any possible allergic reaction.