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In feite wordt een kleine hoeveelheid codeïne in het lichaam omgezet in morfine. Het precieze werkingsmechanisme van codeïne is niet bekend; net als morfine bindt codeïne zich echter aan receptoren in de hersenen (opioïde receptoren) die belangrijk zijn voor het overbrengen van pijnsensatie door het lichaam en de hersenen. Codeïne verhoogt de pijntolerantie, vermindert het ongemak, maar pijn is nog steeds merkbaar voor de patiënt. Naast het verminderen van pijn, veroorzaakt codeïne ook kalmerende slaperigheid en onderdrukt het de ademhaling. Codeïne wordt vaak gebruikt in combinatie met paracetamol (Tylenol) of aspirine voor een effectievere pijnverlichting. Koop codeïne online.

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