Orthobiologics is a relatively new idea to use growth factors to help musculoskeletal lesions recover. The focus of research has switched from recombinant growth factors to autologous blood products because of their high cost, short lifespan, ineffective delivery method, and need for high doses to produce therapeutic benefits. 6 Historically, the first description of autogenous fibrin gel was made in 1990. Marx et al.,12 (1998), who presented a case series of 88 patients who had a mandibular continuity defect and were treated with bone grafting, employed Platelet Rich Plasma for the first time in bone repair. In half of these patients, Platelet Rich Plasma was given to the graft, and subsequent radiographs of these patients showed that the graft had become more mature and had consolidated.
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