How is ultra-low-dose naltrexone clinically important?

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How is ultra-low-dose naltrexone clinically important?

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How is ultra-low-dose naltrexone clinically important?

Ultra low-dose naltrexone or naloxone (ULDN) refers to a dosing spectrum when less than one ?g quantity of the naltrexone is used. Its mechanism of action is linked to a bimodal cellular response to opioids. Additionally to their inhibitory Gi-coupled response, concomitant and mild Gs-coupled stimulatory response are also induced by opioids.

How is ultra-low-dose naltrexone clinically important?

Ultra low-dose naltrexone or naloxone (ULDN) refers to a dosing spectrum when less than one μg quantity of the naltrexone is used. Its mechanism of action is linked to a bimodal cellular response to opioids. Additionally to their inhibitory Gi-coupled response, concomitant and mild Gs-coupled stimulatory response are also induced by opioids.

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