Cushing's syndrome might be difficult to identify. Fatigue and weight gain can be caused by a variety of factors. Cushings syndrome is sometimes confused with other illnesses that exhibit many of the same symptoms, such as polycystic ovary syndrome or metabolic syndrome. Your doctor will first seek to rule out any other possible causes. Your medical history, physical exam, and lab testing are used to make a diagnosis. Before scheduling lab tests, your doctor may inquire about your use of glucocorticoids or injections and rule them out. Cushing's syndrome can be diagnosed using urine, saliva, or blood testing. A follow-up test is sometimes performed to determine whether the excess cortisol is due to Cushing's syndrome or another cause.
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