Edible insects are remarkable in that many species may be presumed to have been ingested by humans during the entirety of hominid existence; nevertheless, the history of use for a specific edible species is not extensively documented. As a result, while traditional use is largely uncontested, modern-day safety requirements necessitate, in addition to the severe requirement for analytic product identification, a sufficient preclinical safety history, including clinical studies to substantiate safety claims.
Clinical studies are not a universal requirement of regulatory GRAS dossiers, but they are mandated by the use of function and illness mitigation health claims as relevant for Edible Insects-derived foods (ICH, 1996). These studies are expensive to conduct, including substantial preparation as well as test-subject regulation and supervision; nonetheless, detailed and exact reporting can enable reliable safety evaluation for certain groups, particularly those of potentially sensitive persons.
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