Osteoporosis Drugs
A break or fracture in the centre of the thighbone is a relatively unusual side effect of bisphosphonates and denosumab. This injury, known as an atypical femoral fracture, can produce discomfort in the thigh or groyne that starts slowly and worsens over time. Bisphosphonates and denosumab can also induce osteonecrosis of the jaw, a rare disorder in which a piece of jawbone heals slowly or fails to heal, usually following tooth extraction or other invasive dental procedures. This is more likely in persons with bone cancer who take significantly higher dosages of a bisphosphonate than those generally used for Osteoporosis Drugs.
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