Organ-on-a-chip technology provides a revolutionary in vitro platform capable of more accurately mimicking physiological activities of in vivo tissue than conventional cell-based model systems. Many novel illnesses are the consequence of complicated interactions between numerous organs. Organ-on-a-chip technology, which realises diverse organ functions on a chip, has the potential to be beneficial for developing models of such complicated disorders.
Pharmacokinetic (PK) models give a mathematical framework for analysing the interaction of organs that involves molecular transport and response. These biomimetic, microfluidic devices are often tiny in size and increasing in complexity. Skin-centred Organ on a Chip applications have been explored, with the goal of accommodating a bioengineered skin equivalent that is continually perfused through a microvascular channel.
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