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The Dual Specificity Protein Kinase TTK is critical for mitosis and clonogenicity
The Dual Specificity Protein Kinase TTK is critical for mitosis and clonogenicity
Dual Specificity Protein Kinase TTK

The knockdown of the Dual Specificity Protein Kinase TTK gene, a dual-specificity protein kinase, accelerated GBM tumor development in vivo. Two GSCs were transfected with siTTK or a control lentivirus in this investigation. In the presence of TTK, siTTK-transfected GSCs formed tumors more quickly and lived for a shorter time. TTK is necessary for GSC development and tumorigenesis, according to the findings.

Researchers looked at the effect of TTK knockdown on tumor formation in vivo in a recent study. They compared two separate GSCs (GSCs) to GSCs that had not been transfected with siTTK. Control lentivirus-injected cells had a lower rate of tumor development and a higher rate of survival. TTK is necessary for tumor development and proliferation in GSCs, according to the findings.



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