Self-assembling Vaccines: Introduction
- Vaccines are one of the major and effective interventions that help prevent spread for diseases. These help in reducing infectious diseases and save millions of lives globally each year.
- Increase in understanding of self-assembly of viral proteins and virus-like particles (VLPs) has opened new opportunities in the development of chimeric VLPs, displaying heterologous epitopes attached to VLPs. Epitopes can be attached by covalent modification or through genetic engineering.
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- Self-assembling vaccines, such as VaxCelerate, were developed by rapidly generating and performing pre-clinically testing a vaccine against a particular pathogen. Mixing MAV strain with biotinylated pathogen specific immunogenic peptides yields a self-assembled vaccine.
Key Drivers and Restraints of Global Self-assembling Vaccines Market
- The global self-assembling vaccines market is primarily driven by significant investments in the development of self-assembling vaccines for coronavirus and increase in number of academic & research institutes studying vaccine usage for coronavirus
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- Increase in government support for vaccine development, rise in efforts toward research & development of novel vaccines, and high prevalence of infectious diseases are projected to drive the global market during the forecast period
- In March 2020, Ufovax, a spin-off vaccine company from Scripps Research, announced extension of patented self-assembling protein nanoparticle vaccine platform technology to develop a vaccine against the coronavirus SARS-CoV-2
Respiratory Diseases Segment to Account for Major Share of Global Self-assembling Vaccines Market
- In terms of indication, the global self-assembling vaccines market can be classified into respiratory diseases, infectious diseases, cancer, and others
- The respiratory diseases segment is anticipated to dominate the global market during the forecast period, due to increase in the number of research studies determining the use of self-assembling vaccines for COVID-19 and rise in awareness about new therapies for treatment of respiratory infections
- A number of companies are collaborating with academic & research institutes and other pharmaceutical companies for the development of self-assembling vaccines for COVID-19
- In March 2020, Hoth Therapeutics entered into an agreement with Voltron Therapeutics to form a joint venture entity, “HaloVax”, to begin preclinical trials for the development of vaccine for prevention of COVID-19, which is based on VaxCelerate. VaxCelerate, a self-assembling vaccine, is exclusively licensed by Voltron from the Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital (MGH).
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Academic & Research Institutes Segment to Capture Major Share of Global Market
- Based on end-user, the global self-assembling vaccines market can be categorized into hospitals & clinics, ambulatory surgical centers, academic & research institutes, and others
- The academic & research institutes segment is expected to account for major share of the global self-assembling vaccines market by 2027. This is attributed to increase in efforts toward development of self-assembling vaccines, rise in availability of necessary infrastructure for research, and presence on qualified & experienced research professionals.
North America to Dominate Global Self-assembling Vaccines Market
- In terms of region, the global self-assembling vaccines market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America is projected to dominate the global self-assembling vaccines market during the forecast period.
- The market in North America is anticipated to be driven by increase in burden of COVID-19, rise in support from the U.S. Government for vaccine development, and large number of companies signing strategic agreements and entering into partnerships with other prominent players for vaccine co-development
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Key Players Operating in Global Self-assembling Vaccines Market
The global self-assembling vaccines market is highly fragmented, with a large number of domestic players accounting for major market share. Key players operating in the global self-assembling vaccines market are:
- Argos Therapeutics, Inc.
- Icosavax, Inc.
- Hoth Therapeutics
- Voltron Therapeutics
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