Immunomodulators Market, by Product Type (Immunosuppressants (Calcineurin Inhibitors, Glucocorticoids, Antimetabolites, and Others), Immunostimulants (Vaccines, Antibodies, and Others)), by Application (Oncology, Respiratory, HIV, and Others), by End User (Hospitals, Clinics, and Others), and by Region (North America, Europe, Asia Pacific, Middle East, Africa, and Latin America) - Size, Share, Outlook, and Opportunity Analysis, 2021 - 2028
Immunomodulators are chemicals that can aid immune function by altering the immune system's response to a threat, usually in a favorable way. Immunomodulators may be used alone or in combination with other drugs (such as a corticosteroid) to treat nonresponse or intolerance to aminosalicylates, antibiotics, or corticosteroids, to prevent recurrence after surgery, to bolster or optimize the effect of a biologic drug, and to prevent the development of biologic drug resistance, among other things. By product type, they are segmented into immunosuppressants and immunostimulants. Immunosuppressants suppress the immune response in organ transplantation and autoimmune illnesses, whereas immunostimulants boost the immune response in infections, immunodeficiency (such as AIDS), and malignancies.
The global immunomodulators market is estimated to be valued at US$ 91850.0 Million in 2021 and is expected to reach US$ 156378.2 million by 2028, at a CAGR of 7.9% during the forecast period (2021–2028).
Figure 1. Global Immunomodulators Market Share (%), By Region, 2021
Rising prevalence of multiple sclerosis is expected to drive the market growth over the forecast period.
Multiple sclerosis (MS) is the second leading cause of death, after cardiovascular diseases. Rising prevalence of multiple sclerosis is expected to drive the market growth over the forecast period. For instance, according to a report published in the Multiple Sclerosis Journal 2020, MS affected an estimated 2.8 million people around the world (35.9 per 100,000 population). Since 2013, despite the fact that MS has become more common in every part of the world, there are still disparities in prevalence estimates. The average age of diagnosis is 32 years, and the pooled incidence rate across 75 reporting nations is 2.1 per 100,000 people each year. MS affects twice as many women as it does men.
F. Hoffmann-La Roche Ltd., Biogen Inc., Teva Pharmaceutical Industries Ltd., Novartis AG, Amgen, Inc., Bristol-Myers Squibb Company, Merck Sharp & Dohme Corp., Eli Lilly and Company, Abbott Laboratories, Johnson & Johnson, and Pfizer Inc.
Figure 2. Global Immunomodulators Market Share, By Application, 2021
Rising cases of rheumatoid arthritis is expected to boost the market growth.
The number of active clinical trials to develop immunotherapeutic drugs, such as laquinimod, ozanimod, and ponesimod, is expected to drive the global immunomodulators market in the forecast period. Apart from that, the growing need to treat autoimmune diseases such as rheumatoid arthritis is expected to drive demand for immunomodulators. For instance, in 2018, an estimated 400,000 people in the U.K. had rheumatoid arthritis, and an estimated four million people had an autoimmune disease, according to the British Society for Global Immunomodulators.
Global Immunomodulators Market– Impact of Coronavirus (COVID-19) Pandemic
Since the COVID-19 virus outbreak in December 2019, the disease has spread to over 100 countries across the globe and the World Health Organization declared it as a public health emergency in 2020. According to the Coronavirus Disease (COVID-19) Weekly Epidemiological Update by the World Health Organization, the number of COVID-19 cases reported globally as of August 2, 2021, are approximately 198,234,951 confirmed cases with around 4,227,359 deaths. The Coronavirus (COVID-19) outbreak started from Wuhan, China and has spread across continents, affecting various industries globally.
The COVID-19 pandemic is expected to have a favorable impact on the industry in the foreseeable future, owing to increased sales of immunomodulating products. Furthermore, in order to maintain sales, several key players strive to establish a balance between demand and supply. They're also attempting to increase their investments in quality control, refine their R&D efforts, and improve supply chain management.
Global Immunomodulators Market: Restraint
Side effects associated with immunomodulating drugs such as Thalidomide (Thalomid), lenalidomide (Revlimid), and pomalidomide (Pomalyst) include drowsiness, exhaustion, constipation, low blood cell counts, and neuropathy (painful nerve damage). There's also a higher chance of major blood clots formation (that start in the leg and can travel to the lungs). With thalidomide, this is more common than with the other medicines (lenalidomide and pomalidomide). Additionally, strict regulations with respect to clinical studies by regulatory bodies is hampering the market growth.
Key Players
Major players operating in the global immunomodulators market include F. Hoffmann-La Roche Ltd., Biogen Inc., Teva Pharmaceutical Industries Ltd., Novartis AG, Amgen, Inc., Bristol-Myers Squibb Company, Merck Sharp & Dohme Corp., Eli Lilly and Company, Abbott Laboratories, Johnson & Johnson, and Pfizer Inc.
Immunomodulators are medications that either stimulate or inhibit the immune system. They affect the immunological response by modifying the immune system. Immunomodulators function by lowering the amount of antibodies produced in response to foreign antigens, which stimulate immune reactions. Immunosuppressants and immunostimulants are two different categories of immunomodulators. Corticosteroids, thymosin, and immunoglobulins are a few of the Immunomodulators. Cancer, infection, asthma, and other disorders are treated with these drugs. Immunosuppressants are commonly used to avoid organ rejection during various transplant procedures. Immunostimulants could possibly be utilized to treat HIV and cancer.
Inflammatory bowel disease (IBD), notably ulcerative colitis (UC), and Crohn's disease (CD), can be effectively treated with immunomodulators. Immunomodulators are also commonly employed in organ transplants and the treatment of autoimmune illnesses. Steroids are sometimes taken in conjunction with immunomodulators to speed up the effect of immunomodulators. They are used in contemporary vaccination formulations and play an important role in pharmaceuticals. Immunomodulation focuses on manipulating the immune system to reduce infections and other negative health impacts while maintaining precise control to avoid problems such as frequent and recurrent pneumonia, bronchitis, sinus infections, ear infections, meningitis or skin infections, and others. Simultaneously, efforts to improve animal and human health by suppressive or potentiating measures are made.
Market Dynamics
The rising prevalence of autoimmune illnesses such as rheumatoid arthritis, systemic lupus erythematosus (Lupus), juvenile rheumatoid arthritis, inflammatory bowel arthritis, Psoriatic arthritis, and others is a major contributor to the global immunomodulators market's expansion. For instance, according to the National Institutes of Health, up to 23.5 million Americans (almost 7% of the population) had an autoimmune disease in 2017, resulting in a larger patient pool and, in turn, a larger market.
Key features of the study:
Detailed Segmentation:
“*” marked represents similar segmentation in other categories in the respective section.
The global immunomodulators market size is estimated to be valued at US$ 91850.0 Million in 2021 and is expected to exhibit a CAGR of 7.9% between 2021 and 2028.
Rising prevalence of multiple sclerosis, increasing prevalence of autoimmune disorders, rising availability of drugs, and rising number of ongoing clinical trials for the development of immunotherapeutic agents are the major factors driving the growth of market.
The immunosuppressants segment is the leading product type segment in the market.
Side effects associated with immunomodulating drugs and strict regulations with respect to clinical studies by regulatory bodies are the major factors restraining growth of the market.
Major players operating in the market includes F. Hoffmann-La Roche Ltd., Biogen Inc., Teva Pharmaceutical Industries Ltd., Novartis AG, Amgen, Inc., Bristol-Myers Squibb Company, Merck Sharp & Dohme Corp., Eli Lilly and Company, Abbott Laboratories, Johnson & Johnson, and Pfizer Inc.
The global immunomodulators market size is estimated to be valued at US$ 91850.0 Million in 2021 and is expected to exhibit a CAGR of 7.9% between 2021 and 2028.
Rising prevalence of multiple sclerosis, increasing prevalence of autoimmune disorders, rising availability of drugs, and rising number of ongoing clinical trials for the development of immunotherapeutic agents are the major factors driving the growth of market.
The immunosuppressants segment is the leading product type segment in the market.
Side effects associated with immunomodulating drugs and strict regulations with respect to clinical studies by regulatory bodies are the major factors restraining growth of the market.
Major players operating in the market includes F. Hoffmann-La Roche Ltd., Biogen Inc., Teva Pharmaceutical Industries Ltd., Novartis AG, Amgen, Inc., Bristol-Myers Squibb Company, Merck Sharp & Dohme Corp., Eli Lilly and Company, Abbott Laboratories, Johnson & Johnson, and Pfizer Inc.
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