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Leukapheresis, which is typically used for granulocytes, is a rare blood donation procedure. The product is collected using automated apheresis and is used to treat systemic infections in neutropenic patients. The donor is usually a blood relative who has been given stimulating medications (a directed donation), and the product is irradiated to prevent GVHD. The product has a 24-hour shelf life from the time it is collected and is frequently transfused before infectious disease testing is completed. It is a last-resort therapy, and its use is controversial and uncommon. Leukapheresis is a technique used in the development of CAR-T cell therapy to obtain leukocytes from a cancer patient or donor, which can then be modified and administered to the patient as a therapeutic dose.
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