Fibrinogenis a protein made by the human body, in the uterine wall. Fibrinogen isproduced in the liver and the blood. It acts as a coagulant and thickener inthe blood. Fibrinogen is used primarily to treat thrombotic thrombosis, acondition that occurs when blood flow to a vein is blocked, usually due to pastinjury or surgery. Fibrinogen may also be used in the treatment of otherconditions, such as those that cause a decrease in blood flow, such as deepvein thrombosis, a condition that can lead to major problems such as pulmonaryembolism and heart attack.
Fibrinogencan be derived from animal sources like pigs and cows. In recent years,however, there have been attempts to use this protein for treating severaldiseases. The most successful of these attempts has been the development offibrinogen concentrates intended for use in the treatment of embolus, a type ofblood product that clots and collects in veins. Several trials, however, havefailed to demonstrate that these products improve the success rates of animalsource fibrinolytic therapies.
Oneof the most common uses for fibrinogenconcentrates is in the process of "aggravation" or thrombotictherapy, in which blood is drawn and infused back into the body after a massivetransfusion. Because the initial amount of blood may be too high, especially incases such as traumatic injuries, or in patients undergoing dialysis, theresultant rise in circulating blood can cause severe discomfort. A method of"aggravation" was first used in the treatment of shock with the aidof a cryoprecipitate, or a solution that crystallizes the blood. While thismethod had been successful in many cases, it had serious drawbacks such as alack of control over the amount of blood that was extracted, and the danger ofbleeding. This is why, until recently, it was not feasible to use a largevolume of a cryoprecipitate on an individual, such as after a massive transfusion.
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