Chemical Products Clarithromycin Basic Attributes
Chemical Products Clarithromycin Description
Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor.Target: Antibacterial; CYP3A4Clarithromycin is a macrolide antibiotic used to treat pharyngitis, tonsillitis, acute maxillary sinusitis, acute bacterial exacerbation of chronic bronchitis, pneumonia (especially atypical pneumonias associated with Chlamydophila pneumoniae), skin and skin structure infections. Clarithromycin prevents bacteria from growing by interfering with their protein synthesis. It binds to the subunit 50S
Chemical Products Clarithromycin Basic Attributes
CAS No：81103-11-9
Molecular Formula ：C38H69NO13
Molecular Mass ：747.95300
Exact Mass ：747.47700
PSA ：182.91000
LogP ：3.2
EINECS ：617-200-4
InChIKeys ：AGOYDEPGAOXOCK-KCBOHYOISA-N
H-bond Acceptor ：14
H-bond Donor ：4
SP3 ：0.95
RBN ：8
Chemical Products Clarithromycin Characteristics
Density ：1.18 g/cm3
Melting Point ：217-220ºC
Bolling Point ：805.5ºC at 760 mmHg
Flash Point ：440.9ºC
Refractive Index ：1.526
Solubility ：99.48mg/L(20 ºC)
Storage Condition ：Store only in original container. Keep container tightly closed.
Vapor Pressure ：2.32X10-25 mm Hg at 25 deg C (est)
Stability ：Store in Freezer
Chemical Products Clarithromycin Safety Information
HS Code ：29419000
UN No. ：NONH for all modes of transport
WGK_Germany ：3
Risk Code ：R22
Safety Instructions ：S26; S36
RTECS No. ：KF4997000
Dangerous Mark ：Xi; Xn
P Code ：P301 + P312 + P330
Hazard Statements ：H302
Toxicity ：LD50 in male, female mice, male, female rats (mg/kg): 2740, 2700, 3470, 2700 orally, 1030, 850, 669, 753 i.p., >5000 all s.c. (Abe)
Chemical Products Clarithromycin Product Usage
1. A semi-synthetic macrolide antibiotic. A derivative of erythromycin
2. Antibacterial
3. Clarithromycin is a semi-synthetic macrolide antibiotic. Clarithromycin is a derivative of Erythromycin (E650000).
4. Clarithromycin (6-methoxyerythromycin) is a macrolide antibiotic active against a broad range of Gram positive bacteria. Clarithromycin was designed to enhance acid stability and improve oral bioavailability compared with erythromycin which is highly unstable to acidic conditions, undergoing a series of internal ketalisations between the 9-keto moiety and alcohols at C6 and C11. Omura and colleagues found that protection of the labile 6-OH group by methylation provided a simple but elegant solution.
5. Labeled Clarithromycin, intended for use as an internal standard for the quantification of Clarithromycin by GC- or LC-mass spectrometry.
6. A macrolide antibiotic and protein synthesis inhibitor
Chemical Products Clarithromycin Material and Products
Material ：
Clarithromycin Impurity Q (10 mg) (N-oxide clarithromycin), MethylIodide, Erythromycin, Benzylchloroformate, Tetrahydrofuran, Formaldehyde, ClarithroMycin 9-OxiMe, Tetrahydropyran, Erythromycin-9-oxime, Erythromycin, 6-O-Methyl-2',4'-Bis-O-(Trimethylsilyl)-, 9-[O-(1-Methoxy-1-Methylethyl)Oxime]
Products ：
2,5-dimethylcyclopentan-1-one, Telithromycin, (10E)-10,11-Didehydro-11-deoxy-6-O-MethylerythroMycin, 2,2-DIMETHYLCYCLOPENTANONE
