Aptamers are short, single-stranded DNA/RNA molecules thatcan selectively bind to a specific target, including peptides, proteins,carbohydrates, toxins, small molecules, and even live cells. In addition tofacilitating biomarker identification, such aptamers can be directly used forcell visualization, cell isolation, and tracking cells in vivo. They can alsobe used to modulate activities of cell receptors and deliver different agentsinto the cells. Moreover, aptamers can be conjugated to drugs, and work asdrug-delivery systems. For instance, aptamers have been conjugated withchemotherapy drugs to turn target and bind to only cancerous cells and leave healthytissue untouched.
Unlike other proteins that are enclosed within vesicles inthe Golfer's basket, aptamers have a vesicle-like exterior which makes themhighly visible in a blood test screen. Aptamers tend to be synthesized fromrandom sequences in a reaction buffer, but natural aptamers do exist also innatural rib switching proteins. Aptamersmay be employed for both simple research and therapeutic purposes, since theycan be administered as macromolecules. Since the action of aptamers is to inhibitprotein synthesis, their primary function is to modulate transcription. Mostcommon biological processes entail movement of messenger ribbons from thepromoters to the transcriptional initiation region, where they stimulate thetranscription process.
Aptamers are revolutionizing healthcare industry by providingthe affinity towards a desired target with high selectivity and specificity.
Read More : https://bit.ly/3xAUurj
