Pemphigus vulgaris is a common auto-immune illness that produces skin inflammation, notably in the mucous membranes of the mouth and nose. It nearly always affects persons in their forties or fifties. Pemphigus vulgaris' primary lesion is a soft blister filled with clear fluid that occurs on healthy or irritated skin. The disorder develops when the immune system produces antibodies against proteins found in healthy skin and mucous membranes. The antibodies break down the connections between the cells, causing fluid to accumulate between the skin layers. This causes skin blisters and erosions.
Patients are usually diagnosed when they have persistent or recurrent redness, thickening, itching or bleeding of the mucous membranes in the nose and cheeks. The primary objective of the therapeutic management of pemphigus vulgaris is initially to control the disease, heal the bullous skin and mucous lesions, and minimize the associated functional impairment. Azathioprine and cyclophosphamide are usually the main pemphigus vulgaris treatment. In mild and moderate cases of pemphigus vulgaris, oral immunosuppressant drugs (cyclophosphamide or methotrexate) are the usual treatment of choice.
There is no cure for pemphigus vulgaris at the moment, although medication can help keep the symptoms under control. The primary goal of pemphigus vulgaris treatment is to repair existing blisters while preventing new ones from emerging. Immunosuppressive medicines such as cyclophosphamide or methotrexate are commonly prescribed by doctors. These medications can prevent the immune system from attacking the mucous lining of the lungs, lowering inflammation and symptoms.
Use of steroids in pemphigus vulgaris treatment can help reduce the harmful activity of the immune system in a short space of time. A doctor may suggest a high dose to get the symptoms under control. The use of steroids can be reduced to the lowest possible dose once your symptoms are under control. A high dose can lead to increased appetite and weight gain, diabetes, thin skin, increased risk of infections, acne, and high blood pressure. Other immunosuppressants used in pemphigus vulgaris treatment include azathioprine, mycophenolate mofetil, ciclosporin and cyclophosphamide. In mild pemphigus vulgaris, corticosteroids are prescribes that can be applied to the skin. Many people need stronger medicine like prednisone or methylprednisolone. These corticosteroids work throughout the body. Use of RCTs with adjuvant therapy with azathioprine, mycophenolate mofetil, cyclophosphamide, cyclosporine, intravenous immunoglobulin, plasma exchange, and infliximab in pemphigus vulgaris treatment is not beneficial for achieving remission.
Souces @ https://www.openpr.com/news/2195017/pemphigus-vulgaris-treatment-is-emerging-economies-with
