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For example, Juvederm Ultra Plus for more severe concerns might be priced at $500-$700. Calcium hydroxylapatite is a mineral-like compound naturally found in human bones. It has been used in dentistry and reconstructive plastic surgery for years with a long track record of safety. Poly-L-lactic acid is a synthetic filler that helps to stimulate collagen production. The average cost of Restylane filler for each syringe is around $550. Restylane-L is similar to the original Restylane in terms of efficacy but also uses a numbing agent, lidocaine in order to reduce discomfort. The average cost is between $500-800 per syringe. The average cost of hyaluronic acid fillers is $682 per syringe. Most people require more than one syringe to achieve the desired results. Botox, on the other hand, is measured in units and typically costs around $10 to $15 per unit. The FDA has approved the use of BOTOX in patients 18 and older, and cosmetic fillers in patients 21 and older.