Photopheresis is a combination of apheresis and photodynamic therapy in which blood is treated with photosensitizing chemicals and then exposed to certain wavelengths of light. Extracorporeal photopheresis is another name for it (ECP). ECP is a leukapheresis-based therapy method licenced by the FDA for the treatment of advanced cutaneous T-cell lymphoma. ECP is also used to treat graft versus host disease (GVHD), atopic dermatitis, scleroderma, lichen planus, lupus erythematosus, Crohn's disease, and type 1 diabetes.
There are many photopheresis products on the market, including open and closed systems, however only the closed system is approved by the US FDA due to the lower danger of contamination and infection during reinfusion. Furthermore, closed systems are more technologically advanced than open systems.
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