Cushings syndrome is a disorder that occurs when your body makes too much of the hormone cortisol over a long period of time. Cortisol is sometimes called the “stress hormone” because it helps your body respond to stress.
Cushings syndrome frequently influences grown-ups, generally matured 30 to 50, yet can likewise happen in youngsters. Cushings syndrome influences around three fold the number of ladies as men. In individuals who have type 2 diabetes and blood glucose levels that stay too high over the long haul, alongside hypertension, Cushing's disorder might be the reason. Individuals who take prescriptions called glucocorticoids, which are like cortisol, additionally can build up Cushing's disorder. This kind of Cushings syndrome is classified "exogenous." More than 10 million Americans take glucocorticoids each year,yet it's not known the number of them build up Cushing's disorder.
Cushing's syndrome is caused by either excessive cortisol-like medication, such as prednisone, or a tumor that either produces or results in the production of excessive cortisol by the adrenal glands. Cases due to a pituitary adenoma are known as Cushing's disease, which is the second most common cause of Cushing's syndrome after medication. A number of other tumors, often referred to as ectopic due to their placement outside the pituitary, may also cause Cushing's. Some of these are associated with inherited disorders such as multiple endocrine neoplasia type 1 and Carney complex. Diagnosis requires a number of steps.The first step is to check the medications a person takes.The second step is to measure levels of cortisol in the urine, saliva or in the blood after taking dexamethasone. If this test is abnormal, the cortisol may be measured late at night.If the cortisol remains high, a blood test for ACTH may be done.
Cushing's syndrome may result from any cause of increased glucocorticoid levels, whether due to medication or internal processes.[9][30] Some sources however do not consider the glucocorticoid medication-induced condition as "Cushing's syndrome" proper, instead using the term "Cushingoid" to describe the medication's side effects which mimic the endogenous condition.
