Genomes can be analysed objectively, whereas capillary sequencing requires prior knowledge of the gene or locus being studied. Next Generation Sequencing, on the other hand, is wholly unselective and used to examine entire genomes or exomes in order to find completely original mutations and disease-causing genes. This might be used in paediatrics to identify the genetic causes of mysterious syndromes. For instance, a national initiative called Deciphering Developmental Disorders that is being conducted at the Wellcome Trust Sanger Institute in conjunction with NHS clinical genetics services aims to identify the genetic causes of developmental delays that go undiagnosed by sequencing the affected individuals' parents and children to find harmful de novo variants.
Novel genes mutated in affected children with comparable clinical features have been successfully identified by combining these molecular data with thorough clinical phenotypic data.
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