Ankylosing spondylitis (AS) is a kind of arthritis that causes long-term inflammation of the spine joints. The joints where the spine meets the pelvis are frequently impacted. Other joints, such as the shoulders or hips, are occasionally implicated. Eye and gastrointestinal issues are also possible. Back discomfort is a common symptom of AS, and it comes and goes. The stiffness of the afflicted joints develops with time.
Although the exact origin of Ankylosing Spondylitis is unclear, a mix of genetic and environmental factors is thought to be involved. More than 85% of people afflicted in the UK carry the HLA-B27 antigen, which is a particular human leukocyte antigen. The underlying process is thought to be autoimmune or auto inflammatory in nature. Symptoms are often used to make a diagnosis, which is supported by medical imaging and blood testing. AS is a kind of seronegative spondyloarthropathy, which means that no rheumatoid factor (RF) antibodies are present. It also falls under the umbrella term axial spondyloarthritis.
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