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All of the ingredients in Colon Renewal are premium quality herbs. They are combined into supplements in a state- of the-art laboratory in the United States. This facility meets and exceeds all national standards and is FDA registered. Although this is not a necessity for a supplement producing facility, the makers of Colon Renewal want to do things right and provide you with the best possible product. This means it needs to be safe and natural. It also means that it must be well researched and effective. Otherwise, why would you use it?