Antiepileptic drugs and tricyclic antidepressants are commonly used to treat neuropathic pain. However, the exact mechanism of their action is still unknown. The use of both groups of drugs is limited by their side effects, as it is difficult to achieve the optimal plasma concentration required for pain control without affecting the patient's well-being.
Tramadol and its mechanism of action
Antiepileptic drugs and tricyclic antidepressants are commonly used to treat neuropathic pain. However, the exact mechanism of their action is still unknown. The use of both groups of drugs is limited by their side effects, as it is difficult to achieve the optimal plasma concentration required for pain control without affecting the patient's well-being.
Initially, neuropathic pain was thought to be refractory to opioids. Only recently have opioids been rediscovered as a potential treatment for neuropathy. Purchase Tramadol Online Cheap The mechanism by which classical opioids suppress pain is mediated by mu receptors. Receptors of this type are located on the pre- and postsynaptic membranes of primary afferent nerve fibers. Their activation on the presynaptic membrane reduces glutamate release. However, at the postsynaptic membrane, this process causes hypopolarization through increased potassium flux. Although the biochemical details are unclear, it is clear that the sedative effect of tramadol has the mu receptor as the main lever.
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