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The knockdown of the Dual Specificity Protein Kinase TTK gene, a dual-specificity protein kinase, accelerated GBM tumor development in vivo. Two GSCs were transfected with siTTK or a control lentivirus in this investigation. In the presence of TTK, siTTK-transfected GSCs formed tumors more quickly and lived for a shorter time. TTK is necessary for GSC development and tumorigenesis, according to the findings.
Researchers looked at the effect of TTK knockdown on tumor formation in vivo in a recent study. They compared two separate GSCs (GSCs) to GSCs that had not been transfected with siTTK. Control lentivirus-injected cells had a lower rate of tumor development and a higher rate of survival. TTK is necessary for tumor development and proliferation in GSCs, according to the findings.
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