Safety Assessment of Tripeptide-1
Safety Assessment of Tripeptide-1
Tripeptide-1, Hexapeptide-12, their metal salts and fatty acyl derivatives, and Palmitoyl Tetrapeptide-7 function primarily as skin conditioning agents, and Palmitoyl Tripeptide-1, Palmitoyl Hexapeptide-12, Tripeptide-1, Copper Tripeptide-1, and Palmitoyl Tetrapeptide-7 are also used in cosmetic products. Typical use concentrations of these ingredients are <10 ppm. The Panel noted that the low use concentrations and negative safety test data reviewed obviate any concerns relating to the safety of these ingredients in cosmetic products. Thus, the Panel concluded that these ingredients are safe in cosmetics in the present practices of use and concentration described in this safety assessment
The safety of Tripeptide-1, Hexapeptide-12, their metal salts and fatty acyl derivatives, and Palmitoyl Tetrapeptide-7 as used in cosmetics (listed below) was reviewed by the Cosmetic Ingredient Review (CIR) Expert Panel (Panel). These ingredients function primarily as skin conditioning agents in cosmetic products.1 The ingredient name, palmitoyl oligopeptide, listed in the web-based International Cosmetic Ingredient Dictionary and Handbook (wINCI; Dictionary) has been retired, because it was vague and indeterminately represented 2 other ingredients. The definition for this ingredient also contained no indication of the peptide sequence(s), a point that the Expert Panel deemed critical to a declaration of safety. Palmitoyl oligopeptide now represented by the name Palmitoyl Tripeptide-1 (Gly-His-Lys [GHK] peptide sequence) or Palmitoyl Hexapeptide-12 (Val-Gly-Val-Ala-Pro-Gly [VGVAPG] peptide sequence) in the Dictionary. Unfortunately, the dictionary recites 2 possible sequences for “Hexapeptide-12,” and relevant safety data be found for only one of these. Accordingly, this safety assessment only addresses Hexapeptide-12 and Tripeptide-1derivative ingredients (eg, Palmitoyl Hexapeptide-12) which contain the peptide sequence Val-Gly-Val-Ala-Pro-Gly. Specifically, the safety of such ingredients, containing the peptide sequence Ala-Pro-Gly-Val-Gly-Val, is not addressed. Thus, the data or conclusions in this safety assessment are not applicable to other peptide sequences. In this report, “Hexapeptide-12” only represents Val-Gly-Val-Ala-Pro-Gly.
