In vitro toxicity screening techniques are critical tools for reducing attrition of innovative drug candidates during the research and development phase. Recent advances in the development of physiologically realistic in vitro model systems show promise for improving the translation of test results to anticipate detrimental effects in humans. The development of advanced technology in molecular and cellular biology has accelerated the progress of life sciences, including toxicology.
Toxicology's emphasis is changing away from whole animals and populations of whole animals and toward the cells and molecules of individual animals and people. Toxicologists have been using these novel approaches to analyse the impact of chemicals on biological systems since the mid-1980s. As a natural evolution, similar technologies are being applied for In Vitro Toxicity Testing. These scientific discoveries, in conjunction with societal and economic concerns, have resulted in a shift in the assessment of product safety and potential danger.
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