Label-free array systems include two types of biosensors such as optical and impedance-based biosensors, including techniques such as surface plasmon resonance, bio-layer interferometry, isothermal titration calorimetry, etc. Label-free array systems are widely used in the drug discovery process by biotechnology and pharmaceutical companies. The system works on the principle of optical interferometry, impedance-based assays, and refractive index to identify and validate new molecules as the possible drug candidates. Furthermore, label-free array systems help reduce the cost and time for drug identification and validation process.
Overexpression of clinical drugs in cells with a high level of sequence specificity. As a proof of principle, the developers of global label-free array systems succeeded in verifying market research conducted on human plasma and blood cells. This achievement paved the way for the development of the first automated, multi-step sequentially mixed system that could identify and measure the level of sequence specific to each sample type. The growth of the independent analysis and verification of data and its utility for personalized medicine led to an increase in the demand for this technology.
These components can be applied to various medical applications and help in the identification of important properties of therapeutic agents that can improve the efficacy of the treatments being administered to patients. For example, new and improved methods of metabolizing drugs, like high rate metabolism and multiple compartment kinetics, have made it possible to identify and monitor metabolite interactions with other drugs and consequently enhance the effectiveness of therapeutic agents.
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