Chemical Products 3-Pyridylboronic acid Characteristics
Appearance ?White to yellow-orange Powder, Crystals and/or Chunks

Density ?1.22±0.1 g/cm3(Predicted)

Melting Point ?>300 °C(lit.)

Bolling Point ?308.8±34.0 °C(Predicted)

Flash Point ?140.5±25.7 °C

Refractive Index ?1.534

Solubility ?Slightly soluble in methanol.

Storage Condition ?0-6°C

BRN ?471943

Chemical Products 3-Pyridylboronic acid Characteristics

Chemical Products 3-Pyridylboronic acid Description

Light Yellow Powder

Chemical Products 3-Pyridylboronic acid Basic Attributes

CAS No:1692-25-7

Molecular Formula :C5H6BNO2

Molecular Mass :122.92

Exact Mass :123.049156

PSA :53.4 A^2

InChIKeys :ABMYEXAYWZJVOV-UHFFFAOYSA-N

H-bond Acceptor :3

H-bond Donor :2

SP3 :0.00

RBN :1

Chemical Products 3-Pyridylboronic acid Characteristics

Appearance :White to yellow-orange Powder, Crystals and/or Chunks

Density :1.22±0.1 g/cm3(Predicted)

Melting Point :>300 °C(lit.)

Bolling Point :308.8±34.0 °C(Predicted)

Flash Point :140.5±25.7 °C

Refractive Index :1.534

Solubility :Slightly soluble in methanol.

Storage Condition :0-6°C

BRN :471943

Chemical Products 3-Pyridylboronic acid Safety Information

Hazard Class :IRRITANT, KEEP COLD

HS Code :29349990

UN No. :NONH for all modes of transport

WGK_Germany :3

Risk Code :36/37/38-22-34-11

Safety Instructions :36/37/39-3-26-45-16

Dangerous Mark :Xn,Xi,C,F

P Code :P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501

Hazard Statements :H302

Hazard Note :Irritant

Chemical Products 3-Pyridylboronic acid Product Usage

Pyridine-3-boronic acid is a boric acid substance that can be used in the Suzuki reaction. It is mainly used in laboratory organic synthesis and in the development of chemical medicine.

Chemical Products 3-Pyridylboronic acid Production Methods

General Procedure for the Preparation of Pyridin-3-yl-Boronic Acids (1-6).; [0275] Compounds 1-6 were prepared by the esterification of the appropriate lithiopyridine followed by hydrolysis as previously reported (Cai et al., Tetrahedron Lett. 43: 4285-4287 (2002) ). The synthesis of pyridin-3-yl-3-boronic acid (1) is representative of compounds 2-6. [0276]/Pyridin-3-yl-3-boronic acid (1). A 500 mL 3-neck flask was charged with toluene (85 mL), cooled to below-60 °C and a solution of n-BuLi (1.6 M in hexanes, 48.6 mL, 77.8 mmol) was added dropwise over 10 min. After the internal temperature reached-60 °C a solution of 3-bromopyridine (6.8 mL, 70.7 mmol) in toluene (30 mL) was added drop wise to keep the internal temperature below-50 °C. A brownish-black solid precipitated and the resultant slurry was stirred for 20 min. THF (30 mL) was added drop-wise to keep the internal temperature below-50 °C and the resultant slurry was stirred for 15 min.