Density ?1.22±0.1 g/cm3(Predicted)
Melting Point ?>300 °C(lit.)
Bolling Point ?308.8±34.0 °C(Predicted)
Flash Point ?140.5±25.7 °C
Refractive Index ?1.534
Solubility ?Slightly soluble in methanol.
Storage Condition ?0-6°C
BRN ?471943
Chemical Products 3-Pyridylboronic acid Characteristics
Chemical Products 3-Pyridylboronic acid Description
Light Yellow Powder
Chemical Products 3-Pyridylboronic acid Basic Attributes
CAS No：1692-25-7
Molecular Formula ：C5H6BNO2
Molecular Mass ：122.92
Exact Mass ：123.049156
PSA ：53.4 A^2
InChIKeys ：ABMYEXAYWZJVOV-UHFFFAOYSA-N
H-bond Acceptor ：3
H-bond Donor ：2
SP3 ：0.00
RBN ：1
Chemical Products 3-Pyridylboronic acid Characteristics
Appearance ：White to yellow-orange Powder, Crystals and/or Chunks
Density ：1.22±0.1 g/cm3(Predicted)
Melting Point ：>300 °C(lit.)
Bolling Point ：308.8±34.0 °C(Predicted)
Flash Point ：140.5±25.7 °C
Refractive Index ：1.534
Solubility ：Slightly soluble in methanol.
Storage Condition ：0-6°C
BRN ：471943
Chemical Products 3-Pyridylboronic acid Safety Information
Hazard Class ：IRRITANT, KEEP COLD
HS Code ：29349990
UN No. ：NONH for all modes of transport
WGK_Germany ：3
Risk Code ：36/37/38-22-34-11
Safety Instructions ：36/37/39-3-26-45-16
Dangerous Mark ：Xn,Xi,C,F
P Code ：P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, P501
Hazard Statements ：H302
Hazard Note ：Irritant
Chemical Products 3-Pyridylboronic acid Product Usage
Pyridine-3-boronic acid is a boric acid substance that can be used in the Suzuki reaction. It is mainly used in laboratory organic synthesis and in the development of chemical medicine.
Chemical Products 3-Pyridylboronic acid Production Methods
General Procedure for the Preparation of Pyridin-3-yl-Boronic Acids (1-6).; [0275] Compounds 1-6 were prepared by the esterification of the appropriate lithiopyridine followed by hydrolysis as previously reported (Cai et al., Tetrahedron Lett. 43: 4285-4287 (2002) ). The synthesis of pyridin-3-yl-3-boronic acid (1) is representative of compounds 2-6. [0276]/Pyridin-3-yl-3-boronic acid (1). A 500 mL 3-neck flask was charged with toluene (85 mL), cooled to below-60 °C and a solution of n-BuLi (1.6 M in hexanes, 48.6 mL, 77.8 mmol) was added dropwise over 10 min. After the internal temperature reached-60 °C a solution of 3-bromopyridine (6.8 mL, 70.7 mmol) in toluene (30 mL) was added drop wise to keep the internal temperature below-50 °C. A brownish-black solid precipitated and the resultant slurry was stirred for 20 min. THF (30 mL) was added drop-wise to keep the internal temperature below-50 °C and the resultant slurry was stirred for 15 min.
