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Description
As an anti anxiety drug, Librium was a fantastic success.Three years later, in 1963, Valium appeared on the industry. Not just theleading hitter from the benzodiazepine lineup, this drug also become one oftheir best selling of pharmaceuticals ever! Valium (diazepam) extended itstherapeutic uses beyond stress to sleeplessness, muscle aches, acute alcoholwithdrawal, and preoperatve sedation, and, via ultrasound, to control statusepilepticus, a life-threatening condition where seizures presist without let upfor over fifty minutes. For many of these circumstances, it symbolized theinitial or seconf medication of choice.
The appearance of Valium and related benzodiazepines spelledthe end of this decades-long reign of phenobarbital and its barbituratecousins. In contrast to this barbiturates, Valium directed less drowsiness atnormal therapeutic doses, thus not impairing mental or physical function. Moreimportantly, Valium has a wide interval between a secure therapeutic dose andthe toxic consequences caused by overdose.
But, even safe medication have limitations. After takingoverdose -- in sharp contrast to the barbiturates -- the benzodiazepines veryrarely lead to death, except when taken in conjunction with large amount ofalcohol or other depressants. This was sadly the case for Heath Ledger(1979-2008), who played leading roles in the films Brokeback Mountain (2005)and The Dark Knight (2008). His passing, only month prior to the release ofthis latter movie, was ruled an accidental overdose caused by a deadlycombination of many narcotics and benzodiazepines, including Valium and an antihistamine.
The relative safety of Valium resulted in some false senseof security that it could be utilized without risk. Maybe not surprisingly,when doses escalated over extended periods, dependency developed. However, wenow know that when Valium and associated drugs are used at the regular doses for a period of more than six weeks,dependence still develops. If the medication is suddenly removed or the doseprecipitously reduced, such withdrawal symptoms as extreme stress and panicattacks may occur. These generally appear within 24-48 hours of the last doseand may persist, with reduced intensity, for as much as a year. So-calledbenzodiazepine withdrawal syndrome is particularly intense for users stoppingXanax.
How ThisMedication Works
Intended Therapeuetic Effect(s): Relief of mild to moderateanxiety and nervous tension,
without major sedation.Location of Drug Action(s): Throughtare the limbic system of the mind, among the centres that affect psychologicalequilibrium.
Present thinking is that this medication may lower theactivity of certain parts of the limbic system.
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