The scientific interest in adrenachrome pigment
It is time for us to collectively realize these facts and begin to receive rational education.". "Why, how, when, the World Health Organization, where and why should we 'open our eyes' to our society from top to bottom.".
The scientific interest in adrenachrome pigment can be traced back to the 1950s, when Canadian researchers Humphry Osmond and Abram Hoffer put forward what they called the "adrenal pigment hypothesis". After a series of small studies conducted between 1952 and 1954, they concluded that excessive adrenal pigment may cause symptoms of schizophrenia. Except for some failed treatment studies, this theory has not been explored for decades (Hover wrote a paper in 1981 to re-examine this proposal and concluded that it "more accurately explains schizophrenia syndrome than any other competing hypothesis")
However, this hypothesis has affected the public perception of adrenal pigment, making it talk with hallucinogens such as LSD or mescaline. Aldous Huxley described this in his book The Doors of Perception published in 1954; Anthony Burgess called it "drenchrom" in the secret language of A Clockwork Orange. Frank Herbert described such a tall character in Destination: Void, "he looks like a person who has just eaten a handful of pineal gland and washed it off with a pint of adrenal pigment." But the most famous is that in a scene in Las Vegas's Fear and Loathing in Las Vegas, Hunter S. Thompson, a reporter from Gonzo.
Adrenochrome is a compound produced by the oxidation of adrenaline (adrenaline). From 1950s to 1970s, it has been the subject of limited research as a potential cause of schizophrenia. Although there is no medical application at present, the related derivative chromium carbonitride is a hmostatic drug. Although the name of this compound is, it has nothing to do with the element chromium; On the contrary, the ‑ chrome suffix indicates the relationship with color, because the pure adrenal pigment is dark purple.
In vivo and in vitro, the oxidation reaction of converting adrenaline into adrenergic red will occur. In vitro, silver oxide (Ag2O) was used. In solution, the adrenal pigment is pink, and further oxidation of the compound causes it to polymerize into a brown or black melanin compound. Several small-scale studies (involving 15 or fewer subjects) conducted in the 1950s and 1960s reported that adrenocortical pigment can trigger psychotic reactions, such as thinking disorders and withdrawal.
In 1954, researchers Abram Hoffer and Humphry Osmond claimed that adrenal pigment is a neurotoxic and psychotic substance, which may play a role in schizophrenia and other mental diseases.
