A class of antihistamines known as ethylamine also has a diphenyl structure and an ethyl-amine group connected to it. Doxylamine, phenyltoloxamine (Percogesic), and diphenhydramine (Benadryl) are a few examples of medications in this class (Unisom Sleep Tablets). Even though they are among the oldest antihistamine drug classes, they continue to be the most effective at treating allergy symptoms, even outperforming more recent over-the-counter and prescription antihistamines like loratadine (Claritin) and fexofenadine (Allegra). But much more so than many barbiturates, all ethanolamines are very sedative. Due to the significant sleepiness that ethanolamines cause, they are not always acceptable agents for therapy and are often replaced by less potent medications.
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