B cell maturation antigen targeted therapies Market for novel MM immunotherapy and is involved in the pathophysiology of the disease. Complete responses have been documented in strongly pretreated MM patients after treatment with B cell maturation antigen antibody-drug conjugates (ADC), bi-specific T cell engagers, and chimeric antigen receptor T. These and other BCMA-targeted medicines are changing the face of MM treatment and patient outcomes.
The CAR T-cell method has been used to manipulate native antibody or T-cell recognition as well as signalling pathways in some leukemias and lymphomas; the introduction of specific genes via viral vectors allows tumour cells to be recognised, resulting in intense post-infusion CAR T-cell expansion and real tumour cell killing. Multiple B-Cell Maturation Antigen-directed CAR T-cell studies have now been undertaken around the world, primarily in the United States and China, with comparable results of high rates of response-related toxicities like cytokine release syndrome and neurotoxicity. 14–17 years old According to one study, tumour cells expressing as little as 222 BCMA molecules per cell were detected by the CAR T-cell treatment bb2121, implying that even very low levels of BCMA expression are sufficient to activate the killing activity.
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