North America and Asia Pacificare expected to hold large MesenchymalStem Cells Market shares followed by Europe due to the rapid growth intechnological innovations, high disposable incomes, and the well-equippedhealthcare centers, which will lead to the growth and development of MSCsmarket. The implantation of new mesenchymal stem cells in cancer patients isexpected to enhance the growth of MSCs market.
As per the World HealthOrganization (WHO) 2018 Factsheet, Cancer is the second leading cause of deathglobally, and it caused around 9.6 million deaths in 2018 globally. Accordingto the European Journal of Cancer, Europe witnessed over 3.9 million cases ofcancer and around 1.9 million deaths from cancer in the year 2018. Whereas,according to National Center for Biotechnology Information (NCBI), in AsiaPacific, breast cancer in females was found to be around 18.0% in the year 2012and it was the fourth most cause for around 9% death due to cancer in theregion.
Mesenchymal stem cells, alsoknown as Mesenchymal Stromal Cells (MSCs), are adult, fibroblast-likemultipotent cells that can differentiate and mature into tissues of mesodermalorigin such as adipocytes, chondroblasts, and osteoblasts. Mesenchymal stemcells were isolated first time from the bone marrow and later from varioussources such as cord cells, adipose tissue, and molar cells. MSCs in terms ofsize, are smaller and are quite difficult to observe in histological sections.A group of mesenchymal stem cells are called as mesenchyme and is widelydistributed in the body. Mesenchymal cells can multiply in numbers ofspecialized cells and they can grow in-vitro or in-vivo condition.
The mesenchymal stem cells playan important role within an organism for suppression of immune cellsactivation, increase the number of newer cells, reduce cell death or celldamage in the body, and secretion of both neurotrophic and angiogenic factors,which are responsible for stabilizing the extracellular matrix, whentransplanted to the brain, this cells promote the reduction of free radicallevels and enhance synaptic connections of damaged neurons, and increases themyelination of axons. The mesenchymal cells are also able to replace and repairany damaged blood vessel in the cerebrum brain.
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Rise in prevalence ofosteoporosis and increase in cancer incidences are expected to support theglobal market growth
MSCs have the ability to growbone tissues through the bone surface to form new bone, which in turn has thepotency to treat osteoporosis. According to the National Institute of Health(NIH), in 2015, the U.S. accounted for around 53 million people suffering fromosteoporosis or at a high risk due to low bone mass.
According to Osteoporosis Canada,around 1 in 5 men and 1 in 3 women suffer from osteoporotic fracture duringtheir lifetime, whereas osteoporosis causes around 70-90% of 30,000 hipfractures yearly; the annual cost to Canada for treating osteoporosis wasaround US$ 4.0 billion in the year 2012, which is expected to rise in theupcoming years. Furthermore, according to the International OsteoporosisFoundation (IOF), annually around 9.0 million people worldwide are sufferingfrom osteoporosis fractures. The aforementioned factors are expected to bolsterthe Mesenchymal stem cells market growth over the forecast period.
Mesenchymal Stem Cells MarketPlayers
Key players in the market arefocusing on inorganic growth strategies such as acquisition and collaborationin order to expand its research and development activities and geographicalpresence. For instance in February 2019 Pluristem Therapeutics has collaboratedwith the NASA's Ames Research Center to evaluate the potential of Pluristem'sPLX cell therapies in preventing and treating medical conditions caused duringspace missions.
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During space mission astronautsare exposed to a challenging environment that includes radiation andmicrogravity, leading to muscle and bone loss as well as other potentiallyserious medical conditions. The collaboration will explore the possibility thatPLX placenta-based cell therapy products can address these and other persistentnegative effects of space travel on the human body.
In February 2019, BrainStorm CellTherapeutics Inc. announced to expand its clinical trial facility withCleveland Clinic as the first U.S. clinical site contracted for a planned Phase2 open-label, multicenter study of repeated intrathecal administration ofautologous Mesenchymal Stem Cell (MSC-NTF) cells in participants with progressiveMultiple Sclerosis (MS).
Moreover most of the key playersare focusing on new product launch in the global mesenchymal stem cell market.For instance in February 2019, Cytonus Therapeutics has developed Cargocytes afirst-of-its-kind, controllable, cell-based platform technology for delivery ofbiologics. Cargocytes are engineered allogenic cell lines that can carry avariety of small molecule compounds, gene editing therapies, therapeutic RNAs,and powerful biologics such as immune modulating cytokines, antibodies andoncolytic viruses. As a platform technology, cargocyte has many therapeuticapplications and will be commercialized through a blend of internal and partneredprograms.
Some of the key market playersidentified across the value chain of mesenchymal stem cells market are,Pluristem Therapeutics, LonzaThermo, Fisher, ATCC, Bio-Techne, MilliporeSigma,Genlantis, Celprogen, Cell Applications, PromoCell GmbH, Cyagen Biosciences,Human Longevity Inc., Axol Bioscience, Cytori Therapeutics, Eutilex Co.Ltd., IDPharma Co. Ltd., BrainStrom Cell Therapeutics, Cytori Therapeutics Inc., NeoviiBiotech, Angel Biotechnology, California Stem Cell Inc., Stemcelltechnologies Inc.,and Celgene Corporation Inc.
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