The combination of drugs for treating PAH is controversial, as many researchers are of the opinion that these drugs do not work synergistically. A report presented by the American Heart Association suggests that using Iloprost instead of the mentioned drugs may help reduce daytime sleepiness (difficulty staying awake or falling asleep) while improving daytime alertness. Further studies seem to corroborate this statement. It has been observed that patients taking Iloprost to treat pulmonary arterial hypertension were less likely to have serious side effects if compared to those taking a placebo. Similarly, compared to patients taking triiodothyronine, patients in whom SSRI drugs had not been effective showed a significant improvement in pulmonary arterial hypertension treated with Iloprost drugs, while placebo did not show any significant change.
Iloprost drugs are an injectable form of prostaglandin, which was initially developed for the treatment of peritonitis. Today, it is used to treat severe pulmonary hypertension, cerebrovascular ischemia, and photoreceptor keratopathy. It can be used to treat all of these conditions, although it has been shown to be particularly effective in the treatment of CFIDS, angina, and irritable bowel syndrome. The manufacturer of iloprost drugs is AstraZeneca Pharmaceuticals Ltd.
Iloprost, an anti-inflammatory synthetic hormone, is sometimes prescribed in combination with calcium channel blockers to treat coronary artery disease (CAD; narrowing of the arteries that supply blood to the heart) and sleep apnea. Iloprost drugs are generally used to treat various types of pulmonary artery hypertension (PAH; abnormally high blood pressure in the arteries supplying the heart to the lungs, resulting in shortness of breath, fatigue, dizziness, and increased daytime sleepiness). However, some patients with sleep apnea may benefit from using Iloprost instead of other anti-depressants (SSRIs) and other drugs, such as beta-blockers (propranolol) and triiodothyronine.
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