Chemical 5-Bromo-2-methoxypyridine Production Methods
Chemical 5-Bromo-2-methoxypyridine Description
Light yellow liquid
Chemical 5-Bromo-2-methoxypyridine Basic Attributes
CAS No：13472-85-0
Molecular Formula ：C6H6BrNO
Molecular Mass ：188.02
Exact Mass ：186.963272
PSA ：22.1 A^2
LogP ：2.4
InChIKeys ：XADICJHFELMBGX-UHFFFAOYSA-N
H-bond Acceptor ：2
H-bond Donor ：0
SP3 ：0.17
RBN ：1
Chemical 5-Bromo-2-methoxypyridine Characteristics
Appearance ：Clear colorless to slightly yellow Liquid
Density ：1.453 g/mL at 25 °C(lit.)
Melting Point ：80ºC (12 mmHg)
Bolling Point ：80 °C12 mm Hg(lit.)
Flash Point ：205 °F
Refractive Index ：n20/D 1.555(lit.)
BRN ：115150
Chemical 5-Bromo-2-methoxypyridine Safety Information
Hazard Class ：IRRITANT
HS Code ：29349990
UN No. ：NONH for all modes of transport
WGK_Germany ：3
Risk Code ：36/37/38-20/21/22
Safety Instructions ：26-36-36/37/39
Dangerous Mark ：Xi,Xn
P Code ：P261-P305 + P351 + P338
Hazard Statements ：H315-H319-H335
Hazard Note ：Irritant
Chemical 5-Bromo-2-methoxypyridine Product Usage
The structural unit of the β-alanine portion of the αvβ3 antagonist is also the structural unit for the synthesis of a potent and selective somatostatin sst3 receptor antagonist.
Chemical 5-Bromo-2-methoxypyridine Production Methods
Step 1. Step 1. A13k. General Method for Substituted Aniline Formation via Nitroarene Formation Through Nucleophilic Aromatic Substitution, Followed by Reduction ; [] Step 1. 5-Bromo-2-methoxypyridine: A mixture of 2,5-dibromopyridine (5.5 g, 23.2 mmol) and NaOMe (3.76g, 69.6 mmol) in MeOH (60 mL) was heated at 70 °C in a sealed reaction vessel for 42 h, then allowed to cool to room temp. The reaction mixture was treated with water (50 mL) and extracted with EtOAc (2 x 100 mL). The combined organic layers were dried (Na2SO4) and concentrated under reduced pressure to give a pale yellow, volatile oil (4.1g, 95percent yield): TLC (10percent EtOAc / 90percent hexane) Rf 0.57.Reference Example 10 Reference Example 10 A mixture of 2,5-dibromopyridine (5.5 g, 23.2 mmol) and NaOMe (3.76g, 69.6 mmol) in MeOH (60 mL) was heated at 70 °C in a sealed reaction vessel for 42 h, then allowed to cool to room temp. The reaction mixture was treated with water (50 mL) and extracted with EtOAc (2 x 100 mL).
