Chemical 4,6-Dihydroxypyrimidine Description

Chemical 4,6-Dihydroxypyrimidine Description

Chemical 4,6-Dihydroxypyrimidine Description

Light Yellow Powder

Chemical 4,6-Dihydroxypyrimidine Basic Attributes

CAS No：1193-24-4

Molecular Formula ：C4H4N2O2

Molecular Mass ：112.09

Exact Mass ：112.027275

PSA ：61.7

LogP ：-0.9

EINECS ：214-772-3

H-bond Acceptor ：3

H-bond Donor ：2

SP3 ：0.00

RBN ：0

Chemical 4,6-Dihydroxypyrimidine Characteristics

Appearance ：Yellow to orange Powder

Density ：1.4421 (rough estimate)

Melting Point ：>300 °C(lit.)

Bolling Point ：209.98°C (rough estimate)

Flash Point ：170.6±22.3 °C

Refractive Index ：1.4610 (estimate)

Solubility ：H2O: 2.5 g/L (20 º C)

Storage Condition ：Store below +30°C.

BRN ：606433

Chemical 4,6-Dihydroxypyrimidine Safety Information

HS Code ：29335995

UN No. ：NONH for all modes of transport

WGK_Germany ：1

Risk Code ：36/37/38

Safety Instructions ：26-36-37/39

RTECS No. ：UW7523000

Dangerous Mark ：Xi

P Code ：P261-P305 + P351 + P338

Hazard Statements ：H315-H319-H335

Hazard Note ：Irritant

Chemical 4,6-Dihydroxypyrimidine Product Usage

Used in the production of sulfamethoxine and other drugs

Chemical 4,6-Dihydroxypyrimidine Production Methods

80.0 g of dimethyl malonate and 60.0 g of formamide were mixed, At 100 excess sodium methoxide methanol solution was added, incubated for 1h, A mixture of 4, 6-dihydroxypyrimidine sodium salt was obtained; subsequently, the temperature was lowered to 70CConcentrate the methanol and add water to continue to concentrate; then add water to dissolve4, 6-dihydroxypyrimidine sodium salt mixture to form 4, 6-dihydroxypyrimidine reaction solution.The bipolar membrane was used to treat it until the pH of the bipolar membrane treatment solution was 9.0.The resulting bipolar membrane treatment solution was acidified with 131.9 g of 37percent strength by weight hydrochloric acid at 40 ° C, Acidified to a solution pH of 2.5, then the resulting acid solution was suction filtered and dried, 55.9 g of 4, 6-dihydroxypyrimidine product was obtained. After testing, the purity of the product was 98.2percentYield 82.1percent.