Precautions for Using Aluminum Hydroxide
1. Common constipation pertains to dosage. Extended-term high-dose consumption could cause severe constipation, in addition, to form fecal clumps, causing intestinal obstruction. Aluminum may also cause a boost in serum bile acidity concentration. This effect is dose- and time-dependent. Concurrently, based on mortgage loan business bile flow, it might induce abnormal liver and bile functions.
2. Metabolic rateOrendrocrine system: Chemical companies Aluminum hydroxide can match phosphate ions inside the intestine to produce insoluble aluminum phosphate, which is not absorbed with the gastrointestinal tract, which leads to mortgage loan business serum phosphate concentration and a boost in calcium content. Abnormal calcium and phosphorus metabolic rate affect bone formation. Extended-term huge amounts can lead to hypophosphatemia, weak bones, and osteomalacia.
3. Nervous/mental system: A small little bit of aluminum hydroxide is altered into soluble aluminum chloride inside the stomach and absorbed within the gastrointestinal tract. People with kidney insufficiency could cause the strength of aluminum ions inside the bloodstream to enhance. Extended-term usage of aluminum hydroxide in patients with kidney failure could cause aluminum poisoning and mental signs and signs and symptoms. Particularly for patients undergoing hemodialysis, dialysis dementia can occur, which can be manifested as muscle discomfort and twitching, nervousness or sleep problems, abnormal taste, and breathing changes. Slowness and extreme fatigue and weakness.
4. Bloodstream system: Patients with kidney insufficiency can lead to elevated bloodstream aluminum ion concentration, and aluminum is probably the primary cause of anemia in patients with advanced kidney disease. For patients with uremia, excessive aluminum might cause small cell hypochromic anemia, which may be introduced through the inhibition of hemoglobin synthesis, decreased enzyme activity, and decreased iron utilization. Reducing the amount of aluminum hydroxide or using an iron amine chelating agent can effectively correct this symptom.
5. Skin: Throughout taking aluminum hydroxide, patients who're more attentive to aluminum when injected with diphtheria, tetanus toxoid, and pertussis vaccine (DTP triple vaccine) often times have itching, eczema-like lesions, and pigmentation within the injection site.
