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Record Analysis. Data are expressed as means SEM. Each treatment was compared. with control, and record significance between 2 groups was evaluated when using the Student’s t test. A P cost of under .05 was considered statistically significant.
Chemical products RESULTS
The Dose- and Glucose-Dependent Connection between Rebaudioside A
on Insulin Release
Figure 1 demonstrates brought on by rebaudioside A (1016 to
106 mol/L) on glucose-stimulated (16.7 mmol/L) insulin release from mouse islets. Adding growing concentrations of rebaudioside A elicited a sum-dependent rise in
the insulin secretion in the existence of 16.7 mmol/L glucose.
The maximal insulin response was acquired in the effectiveness of 1010 mol/L (P .01) along with the least costly effective dose of
rebaudioside was 1014 mol/L.
Figure 2 shows the final results of rebaudioside A (1010 mol/L)
on insulin secretion from mouse islets inside the glucose concentrations of three.3, 6.6, 11.1, and 16.7 mmol/L, correspondingly. Rebaudioside A potentiated the insulin secretion at blood stream sugar levels
of 11.1 mmol/L or greater (P .05), whereas no stimulatory
effect was detected at normal or low glucose concentrations.
Connection between Rebaudioside A across the Dynamic of Insulin Release
From Perifused Mouse Islets
In the existence of 3.3 mmol/L glucose, adding
rebaudioside A didn't change basal insulin secretion. As expected, the rise in the current glucose level from three.3, to 16.7 mmol/L caused a biphasic insulin response from perifused islets. In the existence of high glucose (16.7 mmol/L),
