Getting cells to correctly assemble the components of the antibody is a challenge in the production of bispecific antibodies. The structure of Bispecific Antibodies is modular. Cells produce 10 configurations when asked to combine the subunits of two different antibodies into one structure, but only one of them is the proper and functional format. Amgen researchers have created antibodies with strategically placed positive and negative electrical charges (denoted by + and - signs) to address this issue. This strategy makes sure that the right subunit pairings are drawn to one another while the wrong ones are repelled. The main outcome is a method that creates fully functional bispecific molecules, which is a significant step in the development of this incredibly promising drug modality.
Read More:
https://cmitoc.blogspot.com/2022/11/bispecific-antibodies-are-used-as.html
