The gene therapy market is projected to grow at an annualized rate of 45%, till 2030
Roots Analysis has done a detailedstudy on Gene Therapy Market (3rd Edition), 2019-2030, coveringkey aspects of the industry’s evolution and identifying potential future growthopportunities.
To order this 670+ page report, which features 190+ figuresand 340+ tables, please visit https://www.rootsanalysis.com/reports/view_document/cell-therapy-manufacturing/285.html
KeyMarket Insights
§ In the past fouryears, more than 31,000 patents related to gene therapies and gene editing havebeen filed / granted; this is indicative of the heightened pace of research in thisdomain
§ Presently, there aremore than 10 approved gene therapies; over 465 product candidates are beingevaluated for the treatment of a variety of disease indications
§ Most of thetherapeutic leads are in the early stages of clinical development; a variety ofviral and non-viral vectors are being used to introduce different types of genemodifications in such therapies
§ Although start-upsand mid-sized companies are spearheading the innovation, several bigbiopharmaceutical companies are also actively engaged
§ With multipleapproved products and several under development, price is one of the majorconcerns in this market; the future is likely to witness the establishment ofmore affordable pricing and reimbursement strategies
§ As several candidatesprogress towards approval, developers are exploring diverse commercializationstrategies to be implemented across different stages of a product’s launchcycle
§ CMOs offering vectormanufacturing services have become an integral part of the gene therapy supplychain, owing to their ability to overcome the various associated challenges
§ Several investors,having realized the untapped opportunity within this emerging segment ofgenetic disorders, have invested over USD 16.5 billion across 280 instances, inthe period between 2014 and 2019
§ Overall, prevalenttrends indicate that the market for gene therapies is poised to growsignificantly as multiple late stage molecules get commercialized in the nearfuture for the treatment of different therapeutic areas
§ The projected futureopportunity is expected to be distributed across different types of genemodifications, therapy delivery routes and key geographical regions
Formore information, please visit https://www.rootsanalysis.com/reports/view_document/gene-therapy-market-3rd-edition-2019-2030/268.html
Table of Contents
1. PREFACE
1.1. Scope of the Report
1.2. Research Methodology
1.3. Chapter Outlines
2. EXECUTIVE SUMMARY
3. INTRODUCTION
3.1. Context and Background
3.2. Evolution of Gene Therapies
3.3. Classification of Gene Therapies
3.3.1. Somatic and Germline Gene Therapy
3.3.2. Ex Vivo and In Vivo Gene Therapy
3.4. Routes of Administration
3.5. Mechanism of Action of Gene Therapies
3.6. Concept of Gene Editing
3.7. Advantages and Disadvantages of Gene Therapies
3.8. Ethical and Social Concerns Related to Gene Therapies
3.9. Future Constraints and Challenges Related to Gene Therapies
3.9.1. Concerns Related to Therapy Development
3.9.2. Concerns Related to Manufacturing
3.9.3. Concerns Related to Commercial Viability
4. GENE DELIVERY VECTORS
4.1. Chapter Overview
4.2. Viral Vectors
4.2.1 Types of Viral Vectors
4.2.1.1. Adeno-associated Viral Vectors
4.2.1.1.1. Overview
4.2.1.1.2. Design
4.2.1.1.3. Advantages
4.2.1.1.4. Limitations
4.2.1.2. Adenoviral Vectors
4.2.1.2.1. Overview
4.2.1.2.2. Design
4.2.1.2.3. Advantages
4.2.1.2.4. Limitations
4.2.1.3. Lentiviral Vectors
4.2.1.3.1. Overview
4.2.1.3.2. Design
4.2.1.3.3. Advantages
4.2.1.3.4. Limitations
4.2.1.4. Retroviral Vectors
4.2.1.4.1. Overview
4.2.1.4.2. Design
4.2.1.4.3. Advantages
4.2.1.4.4. Limitations
4.2.1.5. Other Viral Vectors
4.2.1.5.1. Alphavirus
4.2.1.5.2. Herpes Simplex Virus
4.2.1.5.3. Simian Virus
4.2.1.5.4. Vaccinia Virus
4.3. Non-Viral Vectors
4.3.1. Types of Non-Viral Vectors
4.3.1.1. Plasmid DNA
4.3.1.2. Liposomes, Lipoplexes and Polyplexes
4.3.1.3. Oligonucleotides
4.4. Methods of Transfection
4.4.1. Biolistic Method
4.4.2. Electroporation
4.4.3. Receptor Mediated Gene Delivery
4.4.4. Gene Activated Matrix (GAM)
5. REGULATORY LANDSCAPE AND REIMBURSEMENT SCENARIO
5.1. Chapter Overview
5.2. Regulatory Guidelines in North America
5.2.1. The US Scenario
5.2.2. The Canadian Scenario
5.3. Regulatory Guidelines in Europe
5.4. Regulatory Guidelines in Asia Pacific
5.4.1. Chinese Scenario
5.4.2. Japanese Scenario
5.4.3. South Korean Scenario
5.4.4. Australian Scenario
5.5. Reimbursement Scenario
5.5.1. Challenges Related to Reimbursement
5.6. Payment Models for Gene Therapies
6. COMPETITIVE LANDSCAPE
6.1. Chapter Overview
6.2. Gene Therapy Market: Clinical and Commercial Pipeline
6.2.1. Analysis by Phase of Development
6.2.2. Analysis by Therapeutic Area
6.2.3. Analysis by Type of Vector Used
6.2.4. Analysis by Type of Gene
6.2.5. Analysis by Type of Modification
6.2.6. Analysis by Type of Gene Therapy
6.2.7. Analysis by Route of Administration
6.3. Gene Therapy Market: Early Stage Pipeline
6.3.1. Analysis by Stage of Development
6.3.2. Analysis by Therapeutic Area
6.3.3. Analysis by Type of Vector Used
6.3.4. Analysis by Type of Gene
6.3.5. Analysis by Type of Modification
6.3.6. Analysis by Type of Gene Therapy
6.4. Gene Therapy: Special Designation Awarded
6.4.1. Analysis by Special Designation Awarded
6.5. Key Players: Analysis by Number of Product Candidates
6.6. Developer Landscape
6.6.1. Distribution by Year of Establishment
6.6.2. Distribution by Size of Developer
6.6.3. Distribution by Geographical Location
6.7. Regional Landscape
7. MARKETED GENE THERAPIES
7.1. Chapter Overview
7.2. Gendicine® (Shenzhen Sibiono GeneTech)
7.2.1. Company Overview
7.2.2. Development Timeline
7.2.3. Mechanism of Action and Vectors Used
7.2.4. Target Indication(s)
7.2.5. Current Status of Development
7.2.6. Manufacturing, Dosage and Sales
7.3. Oncorine® (Shanghai Sunway Biotech)
7.3.1. Company Overview
7.3.2. Development Timeline
7.3.3. Mechanism of Action and Vectors Used
7.3.4. Target Indication(s)
7.3.5. Current Status of Development
7.3.6. Manufacturing, Dosage and Sales
7.4. Rexin-G® (Epeius Biotechnologies)
7.4.1. Company Overview
7.4.2. Development Timeline
7.4.3. Mechanism of Action and Vector Used
7.4.4. Target Indication(s)
7.4.5. Current Status of Development
7.4.6. Manufacturing, Dosage and Sales
7.5. Neovasculgen® (Human Stem Cells Institute)
7.5.1. Company Overview
7.5.2. Development Timeline
7.5.3. Mechanism of Action and Vectors Used
7.5.4. Target Indication(s)
7.5.5. Current Status of Development
7.5.6. Manufacturing, Dosage and Sales
7.6. Imlygic® (Amgen)
7.6.1. Company Overview
7.6.2. Development Timeline
7.6.3. Mechanism of Action and Vectors Used
7.6.4. Target Indication(s)
7.6.5. Current Status of Development
7.6.6. Manufacturing, Dosage and Sales
7.7. Strimvelis® (Orchard Therapeutics)
7.7.1. Company Overview
7.7.2. Development Timeline
7.7.3. Mechanism of Action and Vectors Used
7.7.4. Target Indication(s)
7.7.5. Current Status of Development
7.7.6. Manufacturing, Dosage and Sales
7.8. Invossa™ (Kolon TissueGene)
7.8.1. Company Overview
7.8.2. Development Timeline
7.8.3. Mechanism of Action and Vectors Used
7.8.4. Target Indication(s)
7.8.5. Current Status of Development
7.8.6. Manufacturing, Dosage and Sales
7.9. Luxturna™ (Spark Therapeutics)
7.9.1. Company Overview
7.9.2. Development Timeline
7.9.3. Mechanism of Action and Vector Used
7.9.4. Target Indication(s)
7.9.5. Current Status of Development
7.9.6. Manufacturing, Dosage and Sales
7.10. Zolgensma™ (AveXis / Novartis)
7.10.1. Company Overview
7.10.2. Development Timeline
7.10.3. Mechanism of Action and Vector Used
7.10.4. Target Indication(s)
7.10.5. Current Status of Development
7.10.6. Manufacturing, Dosage and Sales
7.11. Collategene® / Beperminogene Perplasmid (AnGes)
7.11.1. Company Overview
7.11.2. Development Timeline
7.11.3. Mechanism of Action and Vector Used
7.11.4. Target Indication(s)
7.11.5. Current Status of Development
7.11.6. Manufacturing, Dosage and Sales
7.12. Zyntelgo™ (bluebird bio)
7.12.1. Company Overview
7.12.2. Development Timeline
7.12.3. Mechanism of Action and Vector Used
7.12.4. Target Indication(s)
7.12.5. Current Status of Development
7.12.6. Manufacturing, Dosage and Sales
8. KEY COMMERCIALIZATION STRATEGIES
8.1. Chapter Overview
8.2. Successful Drug Launch Strategy: ROOTS Framework
8.3. Successful Drug Launch Strategy: Product Differentiation
8.4. Commonly Adopted Commercialization Strategies based onDevelopment Stage of the Product
8.5. Approved Gene Therapies
8.6. Key Commercialization Strategies Adopted by Companies Focusedon Gene Therapy
8.6.1. Strategies Adopted Before Therapy Approval
8.6.2. Strategies Adopted During / Post Therapy Approval
8.7. Concluding Remarks
9. LATE STAGE (PHASE II/III AND ABOVE) GENE THERAPIES
9.1. Chapter Overview
9.2. AMT-061: Overview of Therapy, Current Development Status andClinical Results
9.3. BIIB111 (NSR-REP1): Overview of Therapy, Current DevelopmentStatus and Clinical Results
9.4. BIIB112 (NSR-RPGR): Overview of Therapy, Current DevelopmentStatus and Clinical Results
9.5. BMN 270(valoctocogene roxaparvovec): Overview of Therapy, Current Development Statusand Clinical Results
9.6. E10A: Overview of Therapy, Current Development Status andClinical Results
9.7. FLT180a: Overview of Therapy, Current Development Status andClinical Results
9.8. GS010: Overview of Therapy, Current Development Status andClinical Results
9.9. Instiladrin®: Overview of Therapy, Current Development Statusand Clinical Results
9.10. Lenti-D™: Overview of Therapy, Current Development Status andClinical Results
9.11. LYS-SAF302: Overview of Therapy, Current Development Status andClinical Results
9.12. OTL-101: Overview of Therapy, Current Development Status andClinical Results
9.13. OTL-103: Overview of Therapy, Current Development Status andClinical Results
9.14. OTL-200: Overview of Therapy, Current Development Status andClinical Results
9.15. Pexa-Vec(pexastimogene devacirepvec): Overview of Therapy, Current Development Statusand Clinical Results
9.16. PF-06838435(fidanacogene elaparvovec): Overview of Therapy, Current Development Status andClinical Results
9.17. ProstAtak®: Overview of Therapy, Current Development Status andClinical Results
9.18. SPK-8011: Overview of Therapy, Current Development Status andClinical Results
9.19. Toca 511(vocimagene amiretrorepvec): Overview of Therapy, Current Development Statusand Clinical Results
9.20. VB-111(ofranergene obadenovec): Overview of Therapy, Current Development Status andClinical Results
9.21. VGX-3100: Overview of Therapy, Current Development Status andClinical Results
9.22. Vigil®: Overview of Therapy, Current Development Status andClinical Results
9.23. VM202(donaperminogene seltoplasmid): Overview of Therapy, Current Development Statusand Clinical Results
10. EMERGING TECHNOLOGIES
10.1. Chapter Overview
10.2. Gene Editing Technologies
10.2.1. Overview
10.2.2. Applications
10.3. Emerging Gene Editing Platforms
10.3.1. CRISPR / Cas9 System
10.3.2. TALENs
10.3.3. megaTAL
10.3.4. Zinc Finger Nuclease
10.4. Gene Expression Regulation Technologies
10.5. Technology Platforms for Developing / Delivering Gene Therapies
11. PROMISING THERAPEUTICS AREAS
11.1. Chapter Overview
11.2 Analysis by Special Designations Awarded
11.3. Autoimmune Disorders
11.3.1. Analysis by Target Indication
11.3.2. Analysis by Type of Vector Used
11.4. Cardiovascular Diseases
11.4.1. Analysis by Target Indication
11.4.2. Analysis by Type of Vector Used
11.5. Dermatological Disorders
11.5.1. Analysis by Target Indication
11.5.2. Analysis by Type of Vector Used
11.6. Genetic Disorders
11.6.1. Analysis by Target Indication
11.6.2. Analysis by Type of Vector Used
11.7. Hematological Disorders
11.7.1. Analysis by Target Indication
11.7.2. Analysis by Type of Vector Used
11.8. Infectious Diseases
11.8.1. Analysis by Target Indication
11.8.2. Analysis by Type of Vector Used
11.9. Metabolic Disorders
11.9.1. Analysis by Target Indication
11.9.2. Analysis by Type of Vector Used
11.10. Muscle-related Diseases
11.10.1. Analysis by TargetIndication
11.10.2. Analysis by Type ofVector Used
11.11. Nervous System Disorders
11.11.1. Analysis by TargetIndication
11.11.2. Analysis by Type ofVector Used
11.12. Oncological Disorders
11.12.1. Analysis by TargetIndication
11.12.2. Analysis by Type ofVector Used
11.13. Ophthalmic Diseases
11.13.1. Analysis by TargetIndication
11.13.2. Analysis by Type ofVector Used
12. PATENT ANALYSIS
12.1. Chapter Overview
12.2. Gene Therapy-related Patents
12.2.1. Scope and Methodology
12.2.1.1. Analysis byPublication Year
12.2.1.2. Analysis by GeographicalLocation
12.2.1.3. Analysis by CPCClassification
12.2.1.4. Emerging Focus Areas
12.2.1.5. Leading Players:Analysis by Number of Patents
12.2.1.6. Patent BenchmarkAnalysis
12.2.1.7. Patent ValuationAnalysis
12.3. Gene Editing-related Patents
12.3.1. Scope and Methodology
12.3.1.1. Analysis byPublication Year
12.3.1.2. Analysis byGeographical Location
12.3.1.3. Analysis by CPCClassification
12.3.1.4. Emerging Focus Areas
12.3.1.5. Leading Players:Analysis by Number of Patents
12.3.1.6. Patent BenchmarkAnalysis
12.3.1.7. Patent ValuationAnalysis
12.4. Overall Intellectual Property Portfolio: Analysis by Type ofOrganization
13. MERGERS AND ACQUISITIONS
13.1. Chapter Overview
13.2. Merger and Acquisition Models
13.3. Gene Therapy: Mergers and Acquisitions
13.3.1. Analysis by Year of Mergers and Acquisitions
13.3.2. Analysis by Type of Mergers and Acquisitions
13.3.3. Regional Analysis
13.3.3.1. Continent-wiseDistribution
13.3.3.2. Intercontinental andIntracontinental Deals
13.3.3.3. Country-wiseDistribution
13.3.4. Analysis by Key Value Drivers
13.3.4.1. Analysis by Key ValueDrivers and Year of Acquisition
13.3.5. Analysis by Phase of Development of the Acquired Company’s Product
13.3.6. Analysis by Therapeutic Area
14. FUNDING AND INVESTMENT ANALYSIS
14.1. Chapter Overview
14.2. Types of Funding
14.3. Funding and Investment Analysis
14.3.1. Analysis by Number of Funding Instances
14.3.2. Analysis by Amount Invested
14.3.3. Analysis by Type of Funding
14.3.4. Analysis by Amount Invested across Different Types of Therapies
14.3.5. Regional Analysis by Amount Invested
14.3.6. Most Active Players
14.3.7. Key Investors
14.3.8. Analysis by Stage of Development
14.4. Concluding Remarks
15. COST PRICE ANALYSIS
15.1. Chapter Overview
15.2. Gene Therapy Market: Factors Contributing to the Price of GeneTherapies
15.3. Gene Therapy Market: Pricing Models
15.3.1. On the Basis of Associated Product / Component Costs
15.3.2. On the Basis of Competition
15.3.3. On the Basis of Patient Segment
15.3.4. On the Basis of Opinions of Industry Experts
16. BIG PHARMA PLAYERS: ANALYSIS OF GENE THERAPY RELATEDINITIATIVES
16.1. Chapter Overview
16.2. Top Pharmaceutical Companies
16.2.1. Analysis by Therapeutic Area
16.2.2. Analysis by Type of Vector Used
16.2.3. Analysis by Type of Modification
16.2.4. Analysis by Type of Gene Therapy
16.3. Other Big Pharma Players
17. MARKET FORECAST AND OPPORTUNITY ANALYSIS
17.1. Chapter Overview
17.2. Scope and Limitations
17.3. Key Assumptions and Forecast Methodology
17.4. Overall Gene Therapy Market, 2019-2030
17.4.1. Gene Therapy Market: Analysis by Type of Gene Modification
17.4.2. Gene Therapy Market: Analysis by Type of Therapy
17.4.3. Gene Therapy Market: Analysis by Type of Vector Used
17.4.4. Gene Therapy Market: Analysis by Therapeutic Area
17.4.5. Gene Therapy Market: Analysis by Route of Administration
17.4.6. Gene Therapy Market: Analysis by Geography
17.5. Gene Therapy Market: Value Creation Analysis
17.6. Gene Therapy Market: Product-wise Sales Forecasts
17.6.1. Gendicine®
17.6.1.1. Target PatientPopulation
17.6.1.2. Sales Forecast
17.6.1.3. Net Present Value
17.6.1.4. Value CreationAnalysis
17.6.2. Oncorine®
17.6.2.1. Target Patient Population
17.6.2.2. Sales Forecast
17.6.2.3. Net Present Value
17.6.2.4. Value CreationAnalysis
17.6.3. Rexin-G®
17.6.3.1. Target PatientPopulation
17.6.3.2. Sales Forecast
17.6.3.3. Net Present Value
17.6.3.4. Value CreationAnalysis
17.6.4. Neovasculgen®
17.6.4.1. Target PatientPopulation
17.6.4.2. Sales Forecast
17.6.4.3. Net Present Value
17.6.4.4. Value CreationAnalysis
17.6.5. Strimvelis®
17.6.5.1. Target PatientPopulation
17.6.5.2. Sales Forecast
17.6.5.3. Net Present Value
17.6.5.4. Value CreationAnalysis
17.6.6. Imlygic®
17.6.6.1. Target PatientPopulation
17.6.6.2. Sales Forecast
17.6.6.3. Net Present Value
17.6.6.4. Value CreationAnalysis
17.6.7. Invossa™
17.6.7.1. Target PatientPopulation
17.6.7.2. Sales Forecast
17.6.7.3. Net Present Value
17.6.7.4. Value CreationAnalysis
17.6.8. Luxturna™
17.6.8.1. Target PatientPopulation
17.6.8.2. Sales Forecast
17.6.8.3. Net Present Value
17.6.8.4. Value CreationAnalysis
17.6.9. Zolgensma™
17.6.9.1. Target Patient Population
17.6.9.2. Sales Forecast
17.6.9.3. Net Present Value
17.6.9.4. Value CreationAnalysis
17.6.10. Collategene® /Beperminogene Perplasmid
17.6.10.1. Target PatientPopulation
14.6.10.2. Sales Forecast
17.6.10.3. Net Present Value
17.6.10.4. Value CreationAnalysis
17.6.11. Zyntelgo™
17.6.11.1. Target PatientPopulation
17.6.11.2. Sales Forecast
17.6.11.3. Net Present Value
17.6.11.4. Value CreationAnalysis
17.6.12. AMT-061
17.6.12.1. Target PatientPopulation
17.6.12.2. Sales Forecast
17.6.12.3. Net Present Value
17.6.12.4. Value CreationAnalysis
17.6.13. BIIB111
17.6.13.1. Target PatientPopulation
17.6.13.2. Sales Forecast
17.6.13.3. Net Present Value
17.6.13.4. Value CreationAnalysis
17.6.14. BIIB112
17.6.14.1. Target Patient Population
17.6.14.2. Sales Forecast
17.6.14.3. Net Present Value
17.6.14.4. Value CreationAnalysis
17.6.15. BMN 270
17.6.15.1. Target PatientPopulation
17.6.15.2. Sales Forecast
17.6.15.3. Net Present Value
17.6.15.4. Value CreationAnalysis
17.6.16. E10A
17.6.16.1. Target PatientPopulation
17.6.16.2. Sales Forecast
17.6.16.3. Net Present Value
17.6.16.4. Value CreationAnalysis
17.6.17. FLT180a
17.6.17.1. Target PatientPopulation
17.6.17.2. Sales Forecast
17.6.17.3. Net Present Value
17.6.17.4. Value CreationAnalysis
17.6.18. GS010
17.6.18.1. Target PatientPopulation
17.6.18.2. Sales Forecast
17.6.18.3. Net Present Value
17.6.18.4. Value CreationAnalysis
17.6.19. Instiladrin®
17.6.19.1. Target PatientPopulation
17.6.19.2. Sales Forecast
17.6.19.3. Net Present Value
17.6.19.4. Value CreationAnalysis
17.6.20. Lenti-D™
17.6.20.1. Target PatientPopulation
17.6.20.2. Sales Forecast
17.6.20.3. Net Present Value
17.6.20.4. Value CreationAnalysis
17.6.21. LYS-SAF302
17.6.21.1. Target PatientPopulation
17.6.21.2. Sales Forecast
17.6.21.3. Net Present Value
17.6.21.4. Value CreationAnalysis
17.6.22. OTL-101
17.6.22.1. Target PatientPopulation
17.6.22.2. Sales Forecast
17.6.22.3. Net Present Value
17.6.22.4. Value CreationAnalysis
17.6.23. OTL-103
17.6.23.1. Target PatientPopulation
17.6.23.2. Sales Forecast
17.6.23.3. Net Present Value
17.6.23.4. Value CreationAnalysis
17.6.24. OTL-200
17.6.24.1. Target PatientPopulation
17.6.24.2. Sales Forecast
17.6.24.3. Net Present Value
17.6.24.4. Value CreationAnalysis
17.6.25. Pexa-Vec
17.6.25.1. Target PatientPopulation
17.6.25.2. Sales Forecast
17.6.25.3. Net Present Value
17.6.25.4. Value CreationAnalysis
17.6.26. PF-06838435
17.6.26.1. Target PatientPopulation
17.6.26.2. Sales Forecast
17.6. 26.3. Net Present Value
17.6.26.4. Value CreationAnalysis
17.6.27. ProstAtak®
17.6.27.1. Target PatientPopulation
17.6.27.2. Sales Forecast
17.6.27.3. Net Present Value
17.6.27.4. Value CreationAnalysis
17.6.28. SPK-8011
17.6.28.1. Target PatientPopulation
17.6.28.2. Sales Forecast
17.6.28.3. Net Present Value
17.6.28.4. Value CreationAnalysis
17.6.29. Toca 511
17.6.29.1. Target PatientPopulation
17.6.29.2. Sales Forecast
17.6.29.3. Net Present Value
17.6.29.4. Value CreationAnalysis
17.6.30. VB-111
17.6.30.1. Target PatientPopulation
17.6.30.2. Sales Forecast
17.6.30.3. Net Present Value
17.6.30.4. Value CreationAnalysis
17.6.31. VGX-3100
17.6.31.1. Target Patient Population
17.6.31.2. Sales Forecast
17.6.31.3. Net Present Value
17.6.31.4. Value CreationAnalysis
17.6.32. Vigil®
17.6.32.1. Target PatientPopulation
17.6.32.2. Sales Forecast
17.6.32.3. Net Present Value
17.6.32.4. Value CreationAnalysis
17.6.33. VM202
17.6.33.1. Target PatientPopulation
17.6.33.2. Sales Forecast
17.6.33.3. Net Present Value
17.6.33.4. Value CreationAnalysis
18. VECTOR MANUFACTURING
18.1. Chapter Overview
18.2. Overview of Viral Vector Manufacturing
18.3. Viral Vector Manufacturing Processes
18.3.1. Mode of Vector Production
18.3.2. Adherent and Suspension Cultures
18.3.3. Unit Processes and Multiple Parallel Processes
18.3.4. Cell Culture Systems for Production of Viral Vectors
18.3.5. Culture Media Specifications
18.4. Bioprocessing of Viral Vectors
18.4.1. AAV Vector Production
18.4.2. Adenoviral Vector Production
18.4.3. Lentiviral Vector Production
18.4.4. γ -Retroviral Vector Production
18.5. Challenges Associated with Vector Manufacturing
18.6. Companies Offering Contract Services for Viral and PlasmidVectors
19. CASE STUDY: GENE THERAPY SUPPLY CHAIN
19.1. Chapter Overview
19.2. Overview of the Gene Therapy Supply Chain
19.3. Implementation of Supply Chain Models
19.4. Logistics in Gene Therapy
19.4.1. Logistics Processes for Autologous and Allogeneic Therapies
19.5. Regulatory Supply Chain across the Globe
19.6. Challenges Associated with Gene Therapy Supply Chain
19.7. Optimizing Cell and Advanced Therapies Supply Chain Management
19.8. Recent Developments and Upcoming Trends
20. CONCLUSION
20.1. Chapter Overview
20.2. Key Takeaways
21. INTERVIEW TRANSCRIPTS
21.1. Chapter Overview
21.2. Adam Rogers, Chief Executive Officer, Hemera Biosciences
21.3. Al Hawkins, Chief Executive Officer, Milo Biotechnology
21.4. Buel Dan Rodgers, Founder & Chief Executive Officer, AAVogen
21.5. Cedric Szpirer, Executive & Scientific Director, DelphiGenetics
21.6. ChristopherReinhard, Chief Executive Officer and Chairman, Gene Therapeutics (previouslyknown as Cardium Therapeutics)
21.7. Ryo Kubota, Chairman, President and Chief Executive Officer,Acucela
21.8. Jeffrey HunG, Chief Commercial Officer, Vigene Biosciences
21.9. Marco Schmeer, Project Manager and Tatjana Buchholz, MarketingManager, PlasmidFactory
21.10. Michael Tripletti, Chief Executive Officer, Myonexus Therapeutics
21.11. Robert Jan Lamers, Chief Executive Officer, Arthrogen
21.12. Tom Wilton, Chief Business Officer, LogicBio Therapeutics
22. APPENDIX 1: TABULATED DATA
23. APPENDIX 2: LIST OF COMPANIES AND ORGANIZATIONS
Contact Details
Gaurav Chaudhary
+1 (415) 800 3415
gaurav.chaudhary@rootsanalysis.com
