Spatial OMICS Market is estimated to reach at $1584.22 Mnby 2030

Spatial OMICS Market is estimated to reach at $1584.22 Mnby 2030

The global Spatial OMICS market size is expected to be worth around US$ 584.22 Mn by 2030, according to a new report by Trends Market Research.

The global Spatial OMICS market size was valued at US$ 305.81 Mn in 2020 and is anticipated to grow at a CAGR of 15.05% during forecast period 2021 to 2030.

Growth Factors

 Startups and well-established players continued their product development and launched novel solutions, democratized their offerings beyond innovators, and engaged in mergers & acquisitions. The spatial OMICS field originated from hyperplexed imaging; however, key players have shifted toward the development of spatial transcriptomics solutions and products.

Rapid advances in the sequencing of tissues, genes, and single cells have resulted in the emergence of spatial genomic sequencing. Spatial OMICS techniques offer quantitative gene expression data and visualization of DNA and RNA mapping within tissue sections. The development of novel technologies for spatial OMICS is anticipated to create lucrative opportunities for the fields of translational research as well as diagnostics.

The spatial genomics technology segment is expected to expand at the fastest CAGR throughout the forecast period owing to a rise in the launch of novel platforms. The integration of high-throughput solutions in transcriptomics, genomics, and proteomics studies has enabled determining the link between disease occurrence and genome position.

Report Highlights

The spatial transcriptomics segment dominated the market with a share of 73.56% in 2020. Continuous advancements in sequencing technologies have accelerated the transcriptomic study of single cells. For the comprehensive study of multicellular organisms, efforts are being taken to design novel solutions for high-throughput genomic analysis while maintaining the spatial information of the sample/tissue under observation or subcellular localization of analyzed DNA/RNA.

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The development of various in situ methods enhances the capabilities to explore spatial information in biological investigation. These methods have led to the convergence of function-oriented fields of biochemistry and molecular genetics with structure-focused fields such as histology and embryology, thereby enabling spatially resolved molecular investigation of biological processes.

The consumables segment accounted for the largest share of 63.01% in 2020 owing to the high utilization rate and launch of novel products. For instance, in March 2021, Bruker launched new consumables for the chemical cross-linking of proteins (XL-MS). The new PhoX cross-linker facilitates the purification of protein from XL-MS reaction complex mixtures. Moreover, the company plans to launch three cleavable cross-linkers for cleaving the cross-linkers generated in MS experiments.

The launch of new instruments is directly associated with the development of the consumables. Therefore, this drives the instruments as well as the consumables segment. In December 2020, NanoString announced the development of spatial molecular imager (SMI). It is a next-generation spatial OMICS platform designed for multiplexed protein and RNA analysis for single cells in FFPE tissue samples. The platform is expected to be launched by 2022. 

The instrumental analysis segment dominated the market with a revenue share of 57.69% in 2020. The growth of the segment can be primarily attributed to substantial advancements being performed in instruments such as microscopy and mass spectrometry. Mass spectrometry is one of the most promising tools that is used for quantifying nucleic acid and proteins.

It has several advantages such as high resolution, high speed, and high-throughput operations for profiling of protein, which are later used for analyzing complex biological samples. This facilitates novel applications such as new drug development, biomarker discovery, and diagnostics.

The formalin fixation and paraffin-embedding (FFPE) segment held the largest share of 67.26% in 2020. FFPE is considered a standard sample type that is most used for the preservation of human tissue for clinical diagnosis, and hence it holds a major share in the global market. This technique is considered the best in researching tissue morphology for clinical histopathology and diagnostic purposes.

In addition, FFPE specimens are found in abundance in clinical tissue banks, which contributes to the segment growth. However, they are incompatible with single-cell level transcriptome sequencing owing to RNA degradation and RNA damage during storage and extraction. Hence, researchers are focusing on new approaches for increasing the application of FFPE in spatial transcriptomic studies.

The academic and translational research institutes segment dominated the market with a revenue share of 99.60% in 2020. An increase in the adoption of spatial OMICS to translate real-time tissue responses to an external agent increases the technology’s adoption in translational research. Translational studies in the field of genomics help researchers and healthcare practitioners analyze the behavior of human tissues and cells from different individuals in different environments.

This vital information may lead to the evolution of new and better ways to prevent diseases. For instance, single-cell transcriptomics is found to be useful for neuroscientists to understand cell types forming the brain. These methods help understand the spatial architecture of nervous tissues and evaluate the brain’s function. However, this further requires linking molecular cell types to physiological, morphological, and behavioral factors.

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North America accounted for the largest share of 54.80% in 2020. This can be attributed to the increasing prevalence of cancer, the growing demand for personalized medicine, well-developed healthcare facilities, and the availability of novel diagnostic techniques. The growing morbidity and mortality rates due to cancer and other metabolic, autoimmune, and inflammatory disorders have led to an increase in the need for developing novel therapies, thereby driving the market in this region.

In addition, companies operating in North America are launching new initiatives and programs for discovering and increasing translational applications, which is further contributing to the market growth. For instance, in March 2021, NanoString Technologies, Inc. launched the Technology Access Program (TAP) through which the company will analyze tissue samples of patients using the Spatial Molecular Imager platform and GeoMx Digital Spatial Profiler. Hence, such initiatives help in expanding spatial biology applications in the region.

Key Players

• 10x Genomics
• Dovetail Genomics
• S2 Genomics, Inc.
• NanoString Technologies, Inc.
• Seven Bridges Genomics
• PerkinElmer, Inc.
• Bio-Techne
• Danaher Corporation
• IonPath, Inc.
• Millennium Science Pty Ltd.
• Akoya Biosciences, Inc.
• Fluidigm Corporation
• Diagenode Diagnostics
• Biognosys AG
• Rebus Biosystems
• Ultivue, Inc.
• Vizgen Corp.
• BioSpyder Technologies
• Bruker
• Brooks Automation, Inc. 

Market Segmentation

• Technology Outlook 
• Spatial Transcriptomics
• Sequencing-based Methods
• Laser capture microdissection (LCM), by tissue type
• FFPE tissue samples
• Others
• Transcriptome in-vivo analysis (TIVA)
• In situ sequencing
• Microtomy sequencing
• Microscopy-based RNA Imaging Techniques, by methods        
  • Single Molecule RNA Fluorescence In-Situ Hybridization (smFISH)
  • Padlock Probes/ Rolling Circle Amplification
  • Branched DNA probes

• Spatial Genomics
  • FISH
  • Microscopy-based Live DNA Imaging
  • Genome Perturbation Tools
  • Massively-parallel Sequencing
  • Biochemical Techniques
  • Others
• Spatial Proteomics
  • Imaging Techniques
    • Microscopy
    • Multiplexed Ion Beam Imaging
  • Mass Spectrometry
  • Immunofluorescence Techniques
  • Centrifugation Techniques
  • Others

• Product Outlook 
  • Instruments
    • By Mode
      • Automated
      • Semi-automated
      • Manual
    • By Type
      • Sequencing Platforms
      • IHC
      • Microscopy
      • Flow Cytometry
      • Mass Spectrometry
      • Others
  • Consumables
  • Software
    • Bioinformatics tools
    • Imaging tools
    • Storage and management databases
• Workflow Outlook 
  • Sample Preparation
  • Instrumental Analysis
  • Data Analysis
• Sample Type Outlook
  • FFPE
  • Fresh Frozen
• End-use Outlook (Revenue, USD Million, 2017 - 2028)
  • Academic & Translational Research Institutes
  • Pharmaceutical and Biotechnology Companies

The Spatial OMICS market research report covers definition, classification, product classification, product application, development trend, product technology, competitive landscape, industrial chain structure, industry overview, national policy and planning analysis of the industry, the latest dynamic analysis, etc., and also includes major. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level.

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The report provides size (in terms of volume and value) of Spatial OMICS market for the base year 2020 and the forecast between 2021 and 2030. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.

This report focuses on the global Spatial OMICS market status, future forecast, growth opportunity, key market and key players. The study objectives are to present the Spatial OMICS market development in United States, Europe and China.

It is pertinent to consider that in a volatile global economy, we haven’t just conducted Spatial OMICS market forecasts in terms of CAGR, but also studied the market based on key parameters, including Year-on-Year (Y-o-Y) growth, to comprehend the certainty of the market and to find and present the lucrative opportunities in market.