Protein Purification & Isolation Market size is forecast to reach $7.2 billion by 2025, growing at a CAGR of 9.13% during the forecast period 2020-2025. Protein purification and isolation involves isolating proteins from the source, based on differences in their physical properties. The objective of a protein purification scheme is to retain the largest amount of the functional protein with fewest contaminants. The purification scheme of a protein must be optimized to complete this process in the least number of steps. Ion Exchange Chromatography (IEC) is a purification method aimed at separating proteins based on charge, which is dependent on the composition of the mobile phase. Growing number of technological innovations such as single use technologies and automated purification instruments, increasing amounts of investments and funding’s in the life sciences sector, enhanced application areas such as protein-protein interaction studies, and developments in the field of structure-based drug design are driving the market growth in recent years.
Technology - Segment Analysis
Preparative Chromatography Techniques held the largest share in the technology segment of Protein Purification & Isolation Market in 2019, and are estimated to grow at a CAGR of 6.9% during the forecast period 2020-2025. High end user driven applications of ion exchange and affinity chromatography primarily drives the growth of this segment. There has been a rapid rise in the utilization of ion exchange resins for water treatment owing to the presence of various contaminants such as pollutants, factory wastes and pathogenic microorganisms in the drinking water. This is one of the primary factors driving the growth of the global ion exchange. On the other hand, affinity chromatography is driven by applications of purification of monoclonal antibodies, affinity tagged proteins, and other bio-molecules. It is estimated that electrophoresis is likely to be the fastest growing segment and set to register the highest CAGR during the forecast period 2020-2025, owing to increased investment uptakes in the segment by key market players and growing usage of gel electrophoresis and capillary electrophoresis.
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Application - Segment Analysis
Drug Screening held the major share in the application segment of Protein Purification & Isolation Market in 2019. Growing incidences of mortality owing to mortality resulting from various types of drugs, and increasing focus on implementing comprehensive drug and alcohol testing measures are driving the demand of this segment. This has led to considerable increase in market growth of the segment in recent years. Protein Therapeutics is forecast to grow at the fastest rate with the highest CAGR during the forecast period 2020-2025, owing to increase in prevalence of chronic diseases, development of plasma-derived therapies and surge in awareness with respect to protein therapeutics among the population.
Geography - Segment Analysis
North America dominates the geography segment of Protein Purification & Isolation Market with a share of more than 39.7% in 2019, followed by Europe. Entry of large numbers of protein purification market players in the region, developed research and development infrastructure, and technological advancements in the proteomics field in the last decade have attributed to the vast market growth in the region. Europe held the second place in the geography segment share of the market. In Europe, rise in the demand for Protein Purification & Isolation Industry owing to increased awareness about its benefits and the protein market expansion in the region through launch of new market players have helped the market.
Asia-Pacific is estimated to grow at the fastest rate at a higher CAGR during the forecast period 2020-2025. This is owing to rising demand for accurately identifying new ligands, development rapid purification kits that can screen, prepare, purify, and concentrate protein samples and increasing research and development trends of new generation therapies.
Drivers – Protein Purification & Isolation Market
Growing number of technological innovations
The manufacturing of recombinant products by fermentation and purification in stainless steel vessels has seen the transition from small scale to large scale and further to single use disposable technology. The requirement to develop and modulate the process has arisen from the cost and manufacturers need to move the facility on mobile platforms. Major Key players are diving investments into these rising innovations. This is set to drive the market growth in the forecast years 2020-2025.
Growing need to identify new ligands and rapid purification kits
New refolding methods can also be coupled with protein microarray and a means of analytical detection (such as fluorescence signals) to identify new binding ligands when applied to a collection of rapidly refolded cell surface receptors. Refolded receptors can be immobilized on carrier surfaces by affinity capture, noncovalent adsorption, or covalent binding, which are set to give way to new applications in biotechnology. This is set to help in market growth during the forecast period 2020-2025.
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Challenges – Protein Purification & Isolation Market
High expenditure of purification instruments
In general, optimization of protein can only be achieved at the expense of high costs. The higher costs also vary depending on whether a purification step is used for capture, intermediate purification or polishing. Thus, it is anticipated to hamper the market growth during the forecast period 2020-2025.
Protein Purification & Isolation Industry Outlook
Product launches, mergers and acquisitions, joint ventures and R&D activities are key strategies adopted by players in the Protein Purification & Isolation Market. In 2019, the top players present in the market consolidate Protein Purification & Isolation Market share. Protein Purification & Isolation Market top 10 companies are Thermo Fisher Scientific, Inc., Merck Millipore, QIAGEN N.V., Bio-Rad Laboratories, Inc., Agilent Technologies, Sigma-Aldrich Corporation, Promega Corporation, Purolite Corporation, GE Healthcare Life Sciences, and Roche Applied Science among others.
Acquisitions/Product Launches
In April 2017, Merck announced the launch of its newest high-sensitivity detection platform, SMCxPRO technology, at the American Association for Cancer Research Annual Meeting in Washington, D.C.
In March 2020, Thermo Fisher announced the acquisition of QIAGEN N.V. Thermo Fisher acquired QIAGEN for €39 per share in cash. The offer price represented a premium of approximately 23% to the closing price of QIAGEN’s common stock on the Frankfurt Prime Standard.
Key Takeaways
North America dominated the Protein Purification & Isolation Market in the year 2019 owing to entry of large numbers of market players in the region, developed research and development infrastructure, and technological advancements in the proteomics field. The Protein Purification & Isolation Market scope for different regions will be provided in the final report.
Growing rate of funding from both public and private research organizations for protein research, increased research in the pharmaceutical and biotechnological fields and growing need to identify new ligands and rapid purification kits to rapidly screen is estimated to drive the industry growth during the forecast period 2020-2025.
Detailed analysis on the Strength, Weakness and Opportunities of the prominent players operating in the market will be provided in the Protein Purification & Isolation Market report.
High expenditure of purification instruments and short of skilled professionals is anticipated to hamper the market growth of the Protein Purification & Isolation Industry.
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