It's a technique for separating components based on their molecular weight or size differences.
The stationary phase is a porous polymer matrix with pores that are entirely filled with the mobile phase solvent.
The molecules in the sample are pushed through microporous packing material in specialised columns (gel).
The separation is based on the fact that molecules larger than a particular size are completely prohibited from the pores, while smaller molecules have partial or complete access to the interior of the pores.
As a result of the flow of the mobile phase, bigger molecules will travel down the column unobstructed, without piercing the gel matrix, but smaller molecules would be slowed based on their gel penetration.
Read More: https://bloggerthrive.blogspot.com/2022/02/principle-of-gel-permeation.html
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