A large number of drugs, including CBD gummies, are broken down by the same large family of liver enzymes. About 60 percent of all drugs on the market are metabolized by a liver enzyme called cytochrome P450 , which is the same enzyme that breaks down CBD, explains Henry. Since cannabinoids inhibit the enzymes CYT450 and the liver enzyme CYP-P (glycoprotein UDP glucuronosyltransferase), they have the potential to interact with drugs metabolized by these enzymes.
On the other hand, CBD can induce other enzymes in the same family of liver enzymes called CYP450 to accelerate the breakdown of certain drugs so that they are more effective at increasing doses. If these enzymes break down certain medications, side effects can increase, so your doctor should adjust the dose accordingly.
Studies have shown that CBD can enhance the effect of some common drugs used for blood thinning, such as warfarin, as well as drugs that are at risk for blood thinning, such as ibuprofen2. CBD amplifies the action and effect of these drugs by prolonging their presence in the human body. As a result, taking CBD with blood thinners can increase the risk of bleeding.
According to a 2017 study published in the journal Epilepsy Behavior and Case Reports, CBD oil can have an increased effect on blood thinning drugs such as warfarin, which pushes the drug's presence beyond therapeutic levels. CBD, which is taken with blood pressure medications such as beta blockers, can cause them to double or even lower blood pressure to unhealthy levels more often than others.
Since cytochrome P450 is responsible for the metabolism of many medications, "I would proceed with caution when mixing prescription medications with CBD," Dr. Alloway said. Since most prescription drugs used to treat these conditions are metabolized by Cyto chromium P450, it is possible that CBD could affect or improve treatment.
Healthcare providers needed more information on the interactions between CBD and psychotropic drugs, said much of the information was confusing and contradictory. However, she repeated Dr Alloways' statement that it is wise for patients to be clear with their doctor about the use of CBD before they try it.
There is very little research on Cannabidiol (CBD), the second most commonly found cannabinoid in cannabis and showing evidence of potential health benefits for a wide range of diseases. However, scant research suggests that CBD may be illegal and could have problematic interactions with certain other prescription drugs.
Although these results are far from conclusive, further research on cannabidiol (CBD), the second most common cannabinoid in cannabis and interactions with various medications is needed. Before we can look at how CBD oil interacts with drugs, we must understand how the body generally works and which systems are involved: how CBD is metabolized and how it is influenced by something called the Cytochrome p450 system. Pharmaceutical researchers and physicians use this system to understand, calculate and predict dosages, effects and possible side effects of drugs.
For example, a therapeutic substance in the liver is processed by the system cytochrome P450 and generally healthy scientists use the average time it takes for a drug or drug to be processed by the system to obtain accurate dosage information. However, certain substances have the ability to influence the way the system processes compounds, such as CBD, which can lead to certain drugs being metabolised more slowly than they should be.
