An IV injection of recombinant tissue plasminogen activator(tPA) is the gold standard acute ischemic stroke therapeutics for ischemicstroke, which breaks up clots. Sometimes, tPA can be given up to 4.5 hoursafter stroke symptoms started. Acute ischemic stroke is responsible for almost90% of all strokes. It occurs when blood flow through a brain artery is blockedby a clot, a mass of thickened blood. Acute ischemic stroke is an emergencymedical condition that can be life-threatening and sudden death may result.Moreover, ischemic stroke is a serious condition and requires prompt treatment.Therefore, there is an increasing demand for safe and effective acute ischemicstroke therapeutics worldwide.
Acute ischemic strokes is responsible for more than 90% ofstrokes; thus, there is an increasing demand for acuteischemic stroke therapeutics across the globe, especially in the UnitedStates. The most common type of acute ischemic stroke is called obstetric shock.This is where there is a blood clot (thrombus) in the inside wall of a bloodvessel. Often, this happens in a very small blood vessel (cerebral venoussinus) but it can also occur in a larger vessel such as the jugular vein. Clotformation within an artery can be extremely dangerous because it interfereswith the normal flow of blood to and from the brain.
An embolism is not the only thing that can cause acuteischemic stroke. An embolic stroke occurs when a blood clot that formselsewhere in the body breaks loose and travels to the brain via thebloodstream. Thromboembolism, which causes abnormal swelling within the brain,is also a risk factor for ischemic strokes. A blood clot in an artery is calledarterial thrombosis. This type of blood clot can cause heart attack or stroke. Sometimes,cerebral spinal fluid leaks from the brain, and this can result in ischemia.Some medications may also contribute to the problem, and these include certainanti-inflammatory medications and antidepressants.
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