A new treatment for river blindness has just been developed and approved by the FDA. It’s called ivermectin, and it promises to bring relief to many people who live in rural areas of the world who have been unable to afford the $20,000 cost of that previous treatment per year. If you suffer from river blindness, talk to your doctor today about whether ivermectin could be the treatment you’ve been looking for! Or if you want to learn more about this amazing new medicine, read on for details about how it works and what it can do for you!
Why was ivermectin discovered?
Ivermectin was discovered by a parasitologist in Nigeria. He noticed that people who worked in fields and were exposed to earthworms had fewer cases of river blindness than people who were not exposed to worms.
Years later, scientists were able to create an oral version of ivermectin, which is now given to prevent river blindness. In 2003, it was approved by WHO and UNICEF as part of a program that has reduced river blindness cases from more than 25 million per year down to less than 500,000.
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How does Ivermectin kill microfilariae?
Ivermectin tablets are an anti-filarial drug developed in 1987 by Merck. It kills microfilariae (larvae) of Dirofilaria immitis, a parasitic worm that causes heartworm disease, and Onchocercas volvulus, a parasitic worm that causes river blindness.
Both worms use their microfilariae as a method of transportation from one host to another. Each tablet contains 100mg of ivermectin and can be taken once per year.
Its uses are limited by toxicity side effects caused by its binding with plasma proteins leading to dangerous changes in blood pressure or other vital body functions.
When will Ivermectin be available?
When will ivermectin be available to humans? River blindness is a disease caused by parasitic worms. It affects many parts of Africa and Asia.
People who live in affected areas often have no or limited access to health care, which means they can’t get standard treatment. Ivermectin kills these parasites, but it’s not licensed to treat people—it’s currently only licensed to kill parasites in cattle and horses.
This new study has shown that ivermectin can also safely treat river blindness in humans. This could make it much easier for people living with river blindness to get treatment. But before we start using ivermectin as a treatment, we need to know more about how safe and effective it is.
We need more studies like this one so that we can show regulators that it's safe enough to use on humans too.
Where is it being tested now?
The drug is now being tested on a large scale in Nigeria, South Sudan, and Cameroon. WHO says it has already reached more than 600,000 people so far and that it plans to treat 3 million people in 2016.
Over time, Ivermectin treatment will eliminate river blindness as well as lymphatic filariasis – an unrelated disease that can cause elephantiasis and is spread by a type of mosquito. Together these two diseases affect between 50 million and 70 million people around the world.
To eliminate them, experts say they must be dealt with at their source: in areas where they are most prevalent. That means treating entire communities rather than individuals.
WHO estimates that if ivermectin were distributed widely enough, it could reduce transmission rates by 99 percent within five years. If we want to get rid of [river blindness], we have to go after all three [mosquito-borne] diseases, said Dr. Peter Hotez, dean of Baylor College of Medicine's National School of Tropical Medicine and head of Texas Children's Hospital Center for Vaccine Development in Houston.
We need to go after dengue fever and chikungunya as well, he added. These three diseases are extremely important.
What are the next steps?
Currently, over 200 million people around the world are at risk of contracting river blindness (onchocerciasis).
Ivermectin is a new drug that could dramatically reduce rates of infection and disease. It’s given to cattle in Africa to prevent them from spreading onchocerciasis to humans; however, it’s not regulated by any international health authority.
Before ivermectin can be used as a potential treatment for river blindness in humans, an additional clinical trial will have to take place and also secure regulatory approval from international health authorities. Right now there’s no timeline for when these next steps might happen—or even who will pay for them.
What are the next steps in Africa?
The Carter Center and National Geographic recently brought together experts from around the world to discuss how we could combat river blindness in humans.
Experts agreed that ivermectin is a viable treatment, though doses will need to be adjusted based on a person’s weight and age.
Currently, ivermectin is not approved by the Food and Drug Administration (FDA) for use in humans, so there are barriers that must be overcome before people with river blindness can take advantage of these new treatments.
However, encouraging results could eventually lead to FDA approval. In addition, using ivermectin for humans may also provide an opportunity to help control dengue fever and other neglected tropical diseases. More research is needed before we know if these drugs would work as well in people as they do in animals. In addition, it’s important to note that while ivermectin is safe when used correctly, it should only be taken under medical supervision because it can cause severe reactions if misused or overdosed. Also, pregnant women should avoid taking ivermectin until more information about its safety becomes available.
Where can people learn more?
Check out our where to buy ivermectin guide here, so that you know exactly where to buy ivermectin. Feel free to leave your questions in our comment section below and we will answer them with our help. We have very important information on how to use ivermectin properly, so please ask if you have any questions or concerns at all. Do not try to self-medicate without medical advice. If you are interested in any aspect of medicine but do not know how to feel free to contact us for more information. We would be glad to help you out and point you in a better direction that is suitable for your needs and budget!
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