Hypercalcemia is a condition in which your blood calcium level is abnormally high. Nausea and vomiting, constipation and abdominal (belly) pain, a need to drink more fluids and urinate more, exhaustion, weakness, or muscle soreness, confusion, disorientation, and problems thinking, headaches, and depression are all symptoms of this illness.
Calcitonin (miacalcin), calcimimetics, bisphosphonates, denosumab, prednisone, iv fluids, and diuretics are all used to hypercalcemia treatment. For the initial management of hypercalcemia, intravenous bisphosphonates are the treatment of choice. Calcitonin is a man-made hormone that is relatively safe and harmless. This hypercalcemia treatment decreases bone loss and keeps calcium levels in the blood at normal levels. Bisphosphonates include Actonel or Altevia (risedronate), Fosamax (alendronate), Boniva (ibandronate), Reclast or Zometa (ibandronate), and Reclast or Zometa (ibandronate) (zoledronic acid). Bisphosphonates are used to hypercalcemia treatment by inhibiting osteoclastic bone resorption. They decrease calcium release by interfering with osteoclast-mediated bone resorption. The disorder is treated with injectable bisphosphonates on a regular basis to prevent relapse. Bisphosphonates are less harmful than calcitonin and are more effective than it. Excessive bisphosphonate use can cause hypocalcemia, a condition in which the blood has too little calcium. Bisphosphonates diminish calcium efflux from bone into the circulation by inhibiting bone resorption. In many countries, zoledronic acid is used to treat malignancy-related hypercalcemia.
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