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Key Inclusions
§ A detailed assessment of thecurrent market landscape, featuring a comprehensive list of over 90 CROs thatoffer in vitro ADME testing services, and analyses based on a number ofparameters, such as year of establishment, headquarter location(s), company size,type of additional service(s) offered (in vivo ADME, in silico ADME andtoxicology testing), range of assays offered within in vitro ADME serviceportfolio (blood to plasma ratio, Caco-2 permeability, cytochrome (CYP) enzymeinduction / inhibition, metabolic stability, plasma protein binding, reactionphenotyping and others), type of molecule(s) (biologics and small molecules),and type of clientele (pharmaceutical / biotechnology companies and academic /research institutes).
§ A schematic logo landscape of invitro ADME service providers, highlighting their geographical distribution(on the basis of location of headquarters) and company size (small-sized (1-50employees), mid-sized (51-200 employees), large (201-1,000 employees), and verylarge (>1,000 employees)).
§ A discussion on the variousoutsourcing business models adopted in this domain, along with a list of keyconsiderations that need to be taken into account by industry stakeholderswhile selecting a CRO partner.
§ Elaborate profiles of popular invitro ADME testing service providers, featuring a brief overview of thecompany, its financial information (if available), information on in vitro ADMEservice(s) capabilities, and a comprehensive future outlook.
§ A comprehensive benchmarkanalysis, highlighting the key focus areas of small, mid-sized and largecompanies, comparing their existing capabilities within and beyond theirrespective peer groups, and thereby, providing a means for stakeholders toidentify ways to gain a competitive edge in the industry.
§ A detailed analysis of thevarious mergers and acquisitions that have taken place in this domain,highlighting the trend in the number of companies acquired between 2005-2018,along with the geographical distribution of this activity. The analysis alsofeatures an ownership change matrix, providing a summary of the involvement ofprivate and public sector entities in this domain.
§ A detailed discussion on the various regulatory guidelinesrelated to in vitro ADME testing, which have been laid down by majorinternational / regional regulatory bodies (namely European Medicine Agency(EMA), US Food and Drug Administration (USFDA), Ministry of Health, Labor andWelfare (MHLW), International Council for Harmonisation (ICH) of TechnicalRequirements for Pharmaceuticals for Human Use, the Organization for EconomicCo-operation and Development (OECD), and World Health Organization (WHO)).
The report also features thelikely distribution of the current and forecasted opportunity across importantmarket segments, mentioned below:
§ Type of Molecule
§ Small Molecules
§ Biologics
§ Type of Service
§ Absorption Testing
§ Distribution Testing
§ Metabolism andElimination Testing
§ Type of Assay
§ Caco-2 PermeabilityAssay
§ PAMPA PermeabilityAssay
§ MDCK PermeabilityAssay
§ Protein Binding Assay
§ Blood Brain BarrierAssay
§ Blood to Plasma Ratio
§ Stability / ClearanceAssay
§ Enzyme InductionAssay
§ Enzyme InhibitionAssay
§ Metabolite Profilingand Screening / Identification Assay
§ Metabolite ProductionAssay
§ Reaction PhenotypingAssay
§ TransporterInteractions Assay
§ Target TherapeuticArea
§ Blood Disorders
§ CardiovascularDisorders
§ Gastrointestinal andDigestive Disorders
§ Hormonal Disorders
§ Infectious Diseases
§ ImmunologicalDisorders
§ Metabolic Disorders
§ Mental Disorders
§ NeurologicalDisorders
§ Oncological Disorders
§ Respiratory Disorders
§ Skin Disorders
§ Urogenital Disorders
§ Others
§ Type of Sponsor
§ Industry Players
§ Non-Industry Players
§ Key GeographicalRegions
§ North America
§ Europe
§ Asia-Pacific and Restof the World
Thereport includes detailed transcripts of discussions held with the followingexperts:
§ Dan Close (ChiefScientific Officer, 490 Bio Tech)
§ Sridhar Iyer(Director and Global Head, Business Development, JRFGlobal) and Sarang Gorte (AssistantManager, Business Development, JRFGlobal)
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Key Questions Answered
§ Who are the leadingCROs offering in vitro ADME testing services?
§ What are the keyservices being offered by in vitro ADME testing serviceproviders?
§ What is the trend ofmergers and acquisitions in this domain?
§ Howis the current and future market opportunity likely to be distributed acrosskey market segments?
§ What are theanticipated future trends related to in vitro ADME testing servicesmarket?
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